Doctors of Veterinary Medicine (DVMs) are uniquely qualified to conduct biomedical research in the field of comparative medicine using animal models. Unfortunately, the majority of DVMs do not pursue research careers, partly due to the lack of research training opportunities. Consequently, there is a critical shortage of veterinarian with research backgrounds conducting biomedical research across the nation. This competing renewal proposal for our Animal Model Research for Veterinarians (AMRV) program, which was first funded in 2006 and will expire in July 2011, will train veterinarians to become world-class researchers and will encourage them to pursue a research career after training. By taking advantage of the research strengths of faculty mentors at Virginia Tech, the AMRV program will continue to train veterinarians in areas including animal models of immunology and inflammation, environmental medicine, virology and bacteriology, nutrition and obesity, and genomics. We will continue to recruit from all 28 veterinary medicine colleges throughout the nation including Tuskegee University and the Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM), which ranked 1st and 2nd, respectively, in the percentage of enrolled underrepresented students. A total of 6 new DVMs will be recruited over the next 5-year funding period of the program. In addition, one trainee in our existing AMRV program will continue his third year of training during the first year of the competing renewal. We will recruit one new trainee in year 1, two new trainees each in years 2 and 3, and one new trainee in year 4 of the program. No new trainee is requested in year 5. Trainees will have the option of entering either an MS or PhD program in Biomedical and Veterinary Science (BMVS) at VMRCVM but we will advocate for the PhD track. Mentors will be selected on the basis of their commitment to student training, their cutting-edge research programs, and their ability to secure NIH and other major funding. Opportunities for trainees to work at the Edward Via College of Osteopathic Medicine (VCOM) and the new Virginia Tech Carillion School of Medicine will increase opportunities for studying animal models of human diseases. A unique feature of this program will be a visit to NIH, USDA, and other agencies in the Washington, DC area so that trainees can understand the breadth of research career opportunities available to them. We have successfully administrated our current T32 AMRV program and completed essentially all that we originally proposed during the past 5 years. Thus, renewal of this AMRV program will provide continuity for the current trainees in the program and will enable VMRC to continue to help train the next generation of veterinary biomedical scientists.

Public Health Relevance

Veterinarians are uniquely qualified to conduct biomedical research using animal models, but relatively few go into this field of work due to a lack of research training opportunities. This competing renewal proposal is to continue our NIH-funded Animal Model Research for Veterinarians (AMRV) program that aims to rectify this situation by enrolling veterinarians in a Master's or Ph.D. program that equips them with the fundamentals of conducting hypothesis- driven, cutting-edge biomedical research using state-of-the-art technologies and encourages them to enter into a career in research.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Institutional National Research Service Award (T32)
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National Center for Research Resources Initial Review Group (RIRG)
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Moro, Manuel H
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Virginia Polytechnic Institute and State University
Veterinary Sciences
Schools of Veterinary Medicine
United States
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Yugo, Danielle M; Cossaboom, Caitlin M; Heffron, Connie Lynn et al. (2018) Evidence for an unknown agent antigenically related to the hepatitis E virus in dairy cows in the United States. J Med Virol :
Yugo, Danielle M; Heffron, C Lynn; Ryu, Junghyun et al. (2018) Infection Dynamics of Hepatitis E Virus in Wild-Type and Immunoglobulin Heavy Chain Knockout JH-/- Gnotobiotic Piglets. J Virol 92:
Edwards, Michael; Dai, Rujuan; Ahmed, S Ansar (2018) Our Environment Shapes Us: The Importance of Environment and Sex Differences in Regulation of Autoantibody Production. Front Immunol 9:478
McDaniel, Dylan K; Jo, Ami; Ringel-Scaia, Veronica M et al. (2017) TIPS pentacene loaded PEO-PDLLA core-shell nanoparticles have similar cellular uptake dynamics in M1 and M2 macrophages and in corresponding in vivo microenvironments. Nanomedicine 13:1255-1266
Edwards, Michael R; Dai, Rujuan; Heid, Bettina et al. (2017) Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice. Int Immunol 29:263-276
Coutermarsh-Ott, Sheryl L; Broadway, Katherine M; Scharf, Birgit E et al. (2017) Effect of Salmonella enterica serovar Typhimurium VNP20009 and VNP20009 with restored chemotaxis on 4T1 mouse mammary carcinoma progression. Oncotarget 8:33601-33613
Goswami, Ishan; Coutermarsh-Ott, Sheryl; Morrison, Ryan G et al. (2017) Irreversible electroporation inhibits pro-cancer inflammatory signaling in triple negative breast cancer cells. Bioelectrochemistry 113:42-50
Eden, Kristin; Rothschild, Daniel E; McDaniel, Dylan K et al. (2017) Noncanonical NF-?B signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis. Dis Model Mech 10:1517-1527
Coutermarsh-Ott, Sheryl; Eden, Kristin; Allen, Irving Coy (2016) Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure. J Gen Virol 97:825-38
Coutermarsh-Ott, Sheryl L; Doran, John T; Campbell, Caroline et al. (2016) Caspase-11 Modulates Inflammation and Attenuates Toxoplasma gondii Pathogenesis. Mediators Inflamm 2016:9848263

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