The Comparative Medicine and Pathology training program was initiated in the fall of 2003 and provides state- of-the-art research training to veterinarians. Five years of continuing support are requested in the present application, including support for five trainees in each year of the program. It is anticipated that the majorit of these individuals will have completed a residency in medicine, surgery, or pathology prior to entering the training program. Selection criteria will include: 1) strong interest in research and desire for a career in academic veterinary medicine;2) academic credentials and performance during clinical training/residency;and 3) desirable personal characteristics, including integrity, perseverance, and oral and written communications skills. The training program is located in the College of Veterinary Medicine at the University of Minnesota and is directed by Dr. Cathy Carlson and co-director Dr. David Brown. Thirty-two faculty mentors, all members of the Comparative and Molecular Biosciences (CMB) graduate program, will participate in the training program. These individuals represent a diverse group of disciplines, including pharmacology, cell biology, infectious disease, neurobiology, physiology, genetics, molecular biology, and orthopedics. Trainees without a PhD degree will pursue a PhD in the CMB graduate program, a well-organized, multidisciplinary graduate program that was created to focus graduate education efforts by faculty interested in comparative biomedical sciences and the molecular mechanisms responsible for human and animal health and disease. The goal of the CMB graduate program is to provide students with the broad-based knowledge, quality communication skills, and advanced research training essential for a career as an independent investigator.

Public Health Relevance

This program is highly relevant to public health, as it addresses the ongoing serious shortage of veterinarians with the research expertise necessary to pursue a career as independent investigators in biomedical research. These individuals are critical to the effective translation of biomedical research discoveries made in animal models to new methods of diagnosis and treatment of disease in humans.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZOD1)
Program Officer
Moro, Manuel H
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
Veterinary Sciences
Schools of Veterinary Medicine
United States
Zip Code
Rahe, Michael C; Gustafson, Kevin L; Murtaugh, Michael P (2018) B Cell Tetramer Development for Veterinary Vaccinology. Viral Immunol 31:1-10
Truckenbrod, Emily N; Jameson, Stephen C (2018) The virtuous self-tolerance of virtual memory T cells. EMBO J 37:
Tóth, Ferenc; David, Frédéric H; LaFond, Elizabeth et al. (2017) In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. J Orthop Res 35:868-875
Rahe, Michael C; Murtaugh, Michael P (2017) Interleukin-21 Drives Proliferation and Differentiation of Porcine Memory B Cells into Antibody Secreting Cells. PLoS One 12:e0171171
Wang, Luning; Nissi, Mikko J; Toth, Ferenc et al. (2017) Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans. Magn Reson Med 77:1276-1283
Rahe, Michael C; Murtaugh, Michael P (2017) Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 186:15-18
Rahe, Michael C; Murtaugh, Michael P (2017) Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus. Viruses 9:
McCoy, Annette M; Beeson, Samantha K; Splan, Rebecca K et al. (2016) Identification and validation of risk loci for osteochondrosis in standardbreds. BMC Genomics 17:41
Nissi, Mikko J; Tóth, Ferenc; Wang, Luning et al. (2015) Improved Visualization of Cartilage Canals Using Quantitative Susceptibility Mapping. PLoS One 10:e0132167
Tóth, Ferenc; Nissi, Mikko J; Ellermann, Jutta M et al. (2015) Novel Application of Magnetic Resonance Imaging Demonstrates Characteristic Differences in Vasculature at Predilection Sites of Osteochondritis Dissecans. Am J Sports Med 43:2522-7

Showing the most recent 10 out of 25 publications