This application is the second competing renewal of a T32 program initially funded in 2005 and initiated in 2006. The proposed Research Training Program in Experimental Medicine and Pathology is designed to prepare veterinarians for independent careers in biomedical research. All trainees (n = 6/year) will be at the postdoctoral level with appointments as Research Fellows in appropriate departments of Tulane University or Louisiana State University. The objective of the program remains to prepare veterinarians for independent careers in biomedical research where they can apply their unique constellation of skills to translational research that will impact human and animal health. This training grant is joint venture between Tulane University Health Sciences (includes the School of Medicine, School of Public Health and Tropical Medicine and the Tulane National Primate Research Center-TNPRC) and Louisiana State University (LSU) Schools of Medicine (LSUSOM) and Veterinary Medicine (LSUSVM) with the TNRPC and LSUSVM having the lead roles. Research projects performed while supported by this training grant can be used towards fulfilling the requirements of a PhD at either Tulane or LSU. Training will include instruction in aspects of comparative medicine, pathology and microbial pathogenesis and broad exposure to state-of-the-art investigative tools needed for molecular-mechanism-based biomedical research using animal models. Funding provided by this application will support mentored research training emphasizing bench and translational research using multidisciplinary methods and critical thinking in experimental design, data interpretation, oral and written communication skills and ethical conduct of research. Trainees also receive instruction in preparation of NIH grant applications and will be expected to submit an NIH grant (K01, K08 or R21). The program consists of diverse, highly skilled and productive research mentors and is guided by experienced leadership including an internal steering committee and an external advisory committee. Measure of success include: i) recruitment and retention of trainees to fill all available positions, ii) attainment of a PhD by all 10 eligible trainees with seven of those individuals now in junior faculty positions in academia or scientist positions in industry or government, and iii) an average of 4 publications/trainee from the training period.

Public Health Relevance

Research oriented veterinarians with appropriate training in basic and translational biomedical research have a unique constellation of skills that are essential to the advancement of human health. This is particularly true of emerging infectious diseases, which generally have their origins in animals. The goal of this program is to provide highly skilled veterinarians with additional training to allow them to contribute their unique skils to biomedical research.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Institutional National Research Service Award (T32)
Project #
5T32OD011124-14
Application #
9507974
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Watson, Harold L
Project Start
2005-09-22
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
14
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Tulane University
Department
Pathology
Type
Schools of Medicine
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Crossland, Nicholas A; Alvarez, Xavier; Embers, Monica E (2018) Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques. Am J Pathol 188:672-682
Peterson, Tiffany A; MacLean, Andrew G (2018) Current and Future Therapeutic Strategies for Lentiviral Eradication from Macrophage Reservoirs. J Neuroimmune Pharmacol :
Dufour, Jason P; Russell-Lodrigue, Kasi E; Blair, Robert V (2018) Pseudoaneurysm and Arteriovenous Fistula in a Rhesus Macaque (Macaca mulatta). Comp Med 68:74-79
Calenda, Giulia; Villegas, Guillermo; Barnable, Patrick et al. (2017) MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa. J Acquir Immune Defic Syndr 74:e67-e74
Kawiecki, Anna B; Mayton, E Handly; Dutuze, M Fausta et al. (2017) Tissue tropisms, infection kinetics, histologic lesions, and antibody response of the MR766 strain of Zika virus in a murine model. Virol J 14:82
Harris, Emma K; Verhoeve, Victoria I; Banajee, Kaikhushroo H et al. (2017) Comparative vertical transmission of Rickettsia by Dermacentor variabilis and Amblyomma maculatum. Ticks Tick Borne Dis 8:598-604
Foreman, Taylor W; Veatch, Ashley V; LoBato, Denae N et al. (2017) Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection. Am J Pathol 187:2811-2820
Nelson, Cody S; Cruz, Diana Vera; Tran, Dollnovan et al. (2017) Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. JCI Insight 2:
Hudock, Teresa A; Foreman, Taylor W; Bandyopadhyay, Nirmalya et al. (2017) Hypoxia Sensing and Persistence Genes Are Expressed during the Intragranulomatous Survival of Mycobacterium tuberculosis. Am J Respir Cell Mol Biol 56:637-647
Fletcher, J M; Scudder, C J; Kiupel, M et al. (2016) Hypersomatotropism in 3 Cats without Concurrent Diabetes Mellitus. J Vet Intern Med 30:1216-21

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