Veterinarians, with their broad knowledge of organismal biology are uniquely suited for advancing studies in the field of comparative medicine. The University of Missouri Comparative Medicine Program is an established and preeminent training program that provides comprehensive research training for veterinarians with the goal of producing independent scientists conducting research in the broad field of comparative medicine. The training provides a substantive foundation for a competitive research career through 1) course work and seminars that provide broad exposure to biomedical science and comparative medicine, 2) an intensive three- year research experience to provide research competence, 3) instruction in fundamental concepts of laboratory and project management and development of grant writing skills, and 4) increasingly independent experiences at every stage of the scientific research process. The strengths of this program include an exceptional mentor pool of 48 well-funded faculty offering research opportunities in a broad range of areas related to comparative medicine, including but not limited to, studies in disease pathogenesis, genetics of disease, cryobiology and assisted reproduction, cardiovascular, renal and neurological function, cancer, and biomedical engineering. Furthermore, the presence of a National Mutant Mouse Resource Center, the only National Rat and Swine Resource Centers in the US as well as a BL3-biocontainment facility, one of only 13 in the country, provides a unique and unparalleled training environment for research and characterization of genetically engineered animals. Funds are requested to support six trainees for up to three years of research training under the mentorship of an established MU researcher. Trainees will be expected to design and perform a research project, prepare an extramural grant proposal, present research results at national meetings and publish their findings in high quality peer-reviewed journals. Training will culminate with preparation and defense of a dissertation (PhD) or manuscript (MS). On completion of the training program, trainees will have acquired the necessary skills to become successful, funded investigators whose unique training will position them to become leaders in the Comparative Medicine community.

Public Health Relevance

Advances in the field of comparative medicine have a profound impact on our understanding of human health and disease. Veterinarians bring a unique prospective to the field because of their broad training in animal medicine. Training veterinarians to become successful, independent comparative medicine researchers will position them to contribute to advancing understanding of human health and disease.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Institutional National Research Service Award (T32)
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National Center for Research Resources Initial Review Group (RIRG)
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Moro, Manuel H
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University of Missouri-Columbia
Veterinary Sciences
Schools of Veterinary Medicine
United States
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Hart, Marcia L; Ericsson, Aaron C; Lloyd, K C Kent et al. (2018) Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies. Sci Rep 8:10107
Sprinkle, Megan C; Hooper, Sarah E; Backus, Robert C (2018) Previously undescribed vitamin D C-3 epimer occurs in substantial amounts in the blood of cats. J Feline Med Surg 20:83-90
Haney, Megan M; Ericsson, Aaron C; Lever, Teresa E (2018) Effects of Intraoperative Vagal Nerve Stimulation on the Gastrointestinal Microbiome in a Mouse Model of Amyotrophic Lateral Sclerosis. Comp Med :
Bandara, Nilantha; Stott Reynolds, Tamila J; Schehr, Rebecca et al. (2018) Matched-pair, 86Y/90Y-labeled, bivalent RGD/bombesin antagonist, [RGD-Glu-[DO3A]-6-Ahx-RM2], as a potential theranostic agent for prostate cancer. Nucl Med Biol 62-63:71-77
Hooper, S E; Backus, R; Amelon, S (2018) Effects of dietary selenium and moisture on the physical activity and thyroid axis of cats. J Anim Physiol Anim Nutr (Berl) 102:495-504
Pikula, Jiri; Amelon, Sybill K; Bandouchova, Hana et al. (2017) White-nose syndrome pathology grading in Nearctic and Palearctic bats. PLoS One 12:e0180435
Haney, Megan M; Hinkel, Cameron; Thiessen, Aaron et al. (2017) Creation of resin rodent skulls to reduce animal numbers for stereotactic surgery practice. Lab Anim (NY) 46:41-42
Hart, Marcia L; Ericsson, Aaron C; Franklin, Craig L (2017) Differing Complex Microbiota Alter Disease Severity of the IL-10-/- Mouse Model of Inflammatory Bowel Disease. Front Microbiol 8:792
Toth, Linda A; Trammell, Rita A; Liberati, Teresa et al. (2017) Influence of Chronic Exposure to Simulated Shift Work on Disease and Longevity in Disease-Prone Inbred Mice. Comp Med 67:116-126
Javurek, Angela B; Suresh, Dhananjay; Spollen, William G et al. (2017) Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles. Sci Rep 7:2822

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