The Comparative Medicine and Pathology training program was initiated in the fall of 2003 and provides state-of-the-art research training to veterinarians. Five years of continuing support are requested in the present application, including three years of support for five trainees in each year of the program. It is anticipated that the majority of these individuals will have completed a residency in medicine, surgery, or pathology prior to entering the training program. Selection criteria will include 1) academic credentials and performance during clinical training/residency;2) strong interest in research and a desire for a career in academic veterinary medicine;and 3) desirable personal characteristics, including integrity, perseverance, and communications skills. The training program is located in the College of Veterinary Medicine at the University of Minnesota and is directed by Dr. Cathy Carlson and co-director Dr. David Brown. Thirty-two faculty mentors, all members of the Comparative and Molecular Biosciences (CMB) graduate program, will participate in the training program, and they represent a diverse group of disciplines, including pharmacology, cell biology, infectious disease, neurobiology, physiology, genetics, molecular biology, and orthopedics. Trainees without a PhD degree will pursue a PhD in the CMB graduate program, a well-organized, multidisciplinary graduate program that was created to focus graduate education efforts by faculty interested in comparative biomedical sciences and the molecular mechanisms responsible for human and animal health and disease. The goal of the CMB graduate program is to provide students with the broad-based knowledge, quality communication skills, and advanced research training essential for a career as an independent investigator. PUBLICH

Public Health Relevance

STATEMENT (provided by applicant): This program is highly relevant to public health, as it addresses the ongoing serious shortage of veterinarians with the research expertise necessary to pursue a career as independent investigators in biomedical research. These individuals are critical to the effective translation of biomedical research discoveries made in animal models to new methods of diagnosis and treatment of disease in humans.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Institutional National Research Service Award (T32)
Project #
2T32RR018719-06A1
Application #
7637552
Study Section
Special Emphasis Panel (ZRR1-CM-3 (01))
Program Officer
Watson, William T
Project Start
2003-09-30
Project End
2014-04-30
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
6
Fiscal Year
2009
Total Cost
$377,283
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Robinson, Sally R; Rahe, Michael C; Gray, Diem K et al. (2018) Porcine reproductive and respiratory syndrome virus neutralizing antibodies provide in vivo cross-protection to PRRSV1 and PRRSV2 viral challenge. Virus Res 248:13-23
Ekenstedt, Kari J; Becker, Doreen; Minor, Katie M et al. (2014) An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs. PLoS Genet 10:e1004635
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Schuster, D J; Dykstra, J A; Riedl, M S et al. (2013) Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression. Neurogastroenterol Motil 25:e89-100
Robinson, Sally R; Abrahante, Juan E; Johnson, Craig R et al. (2013) Purifying selection in porcine reproductive and respiratory syndrome virus ORF5a protein influences variation in envelope glycoprotein 5 glycosylation. Infect Genet Evol 20:362-8
Boyce, M K; Trumble, T N; Carlson, C S et al. (2013) Non-terminal animal model of post-traumatic osteoarthritis induced by acute joint injury. Osteoarthritis Cartilage 21:746-55
Robinson, Sally R; Figueiredo, Marina C; Abrahante, Juan E et al. (2013) Immune response to ORF5a protein immunization is not protective against porcine reproductive and respiratory syndrome virus infection. Vet Microbiol 164:281-5
Greggs 3rd, Willie M; Clouser, Christine L; Patterson, Steven E et al. (2012) Discovery of drugs that possess activity against feline leukemia virus. J Gen Virol 93:900-5
Greggs 3rd, Willie M; Clouser, Christine L; Patterson, Steven E et al. (2011) Broadening the use of antiretroviral therapy: the case for feline leukemia virus. Ther Clin Risk Manag 7:115-22

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