The future of dental education and support for biomedical research requires investment in the selection and training of tomorrow?s scientists, including basic, translational or clinical researchers. One of the stated goals of the NIDCR is to ?ensure that a diverse and highly trained workforce is available to address the Nation?s health- related needs in dental, oral, and craniofacial research?. In an effort to achieve this goal, we are seeking renewal of our NIDCR-sponsored Institutional Training program in Oral Health Research which provides an array of training opportunities in craniofacial health research. This grant thus requests support to provide education and intensive, integrated research training for a select cadre of scholars seeking either a PhD degree or post-doctoral training (for both DDS and PhD graduates) with a major focus on dental, orofacial and craniofacial health-related disease processes. Only the most highly qualified and motivated pre-doctoral and post-doctoral candidates will be selected for T90/R90 support. The T90 and R90 award components will allow us to continue to train U.S. citizens and permanent residents, and non-permanent residents, respectively. Outstanding pre-doctoral and post-doctoral trainees will be selected by an Internal Steering Committee (ISC) for an initial 12-month period of support, and provided they demonstrate satisfactory progress, will be awarded support for another 12 months. Trainee mentors will be tenured faculty from either the Herman Ostrow School of Dentistry or the Keck School of Medicine of USC. Mentors have been selected using two simple criteria: 1) they maintain active research profiles and have a significant history of successful mentorship, and/or 2) they have current independent research funding from the NIDCR. Based on these simple criteria the selected mentors? research interests are in alignment with the stated goals of the NIDCR. Additional oversight of the overall operation of the T90/R90 grant will come from an External Advisory Committee (EAC). Both the Herman Ostrow School of Dentistry (HOSD) and the Provost?s Office at USC remain fully committed to this and similar federally supported NRSA training grants, and will ensure that additional financial support is in place to achieve all stated outcomes.

Public Health Relevance

The goal of this grant application is to have the financial resources to provide education and training for a select cadre of scholars seeking either a formal PhD degree or post-doctoral training (for both DDS and PhD graduates) with a major focus on dental, orofacial and craniofacial health-related disease processes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Research Training Award (T90)
Project #
2T90DE021982-06
Application #
9148708
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2011-07-01
Project End
2021-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
6
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Southern California
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90032
Jayne, Jordanna G; Bensman, Timothy J; Schaal, Justin B et al. (2018) Rhesus ?-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. Am J Respir Cell Mol Biol 58:310-319
Zhang, T; Wu, J; Ungvijanpunya, N et al. (2018) Smad6 Methylation Represses NF?B Activation and Periodontal Inflammation. J Dent Res 97:810-819
Teng, Camilla S; Ting, Man-Chun; Farmer, D'Juan T et al. (2018) Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome. Elife 7:
Stucky, Andres; Sedghizadeh, Parish P; Mahabady, Susan et al. (2017) Single-cell genomic analysis of head and neck squamous cell carcinoma. Oncotarget 8:73208-73218
Bensman, Timothy J; Jayne, Jordanna G; Sun, Meiling et al. (2017) Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation. Antimicrob Agents Chemother 61:
Foo, Suan-Sin; Chen, Weiqiang; Chan, Yen et al. (2017) Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy. Nat Microbiol 2:1558-1570
Sedghizadeh, Parish P; Sun, Shuting; Junka, Adam F et al. (2017) Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms. J Med Chem 60:2326-2343
Sedghizadeh, Parish P; Mahabady, Susan; Allen, Carl M (2017) Opportunistic Oral Infections. Dent Clin North Am 61:389-400
Navarro, Sonia; Reddy, Raghava; Lee, Jooeun et al. (2017) Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung. Thorax 72:451-459
Bower, Danielle V; Lansdale, Nick; Navarro, Sonia et al. (2017) SERCA directs cell migration and branching across species and germ layers. Biol Open 6:1458-1471

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