Thegoalofthiscompetitiverenewalapplicationistoprovideavarietyofcomplementarytrainingopportunities indentalandcraniofacialresearchattheUniversityofIowa(UI)andtodevelopacohortofbasicresearchers anddentalscholarswhoseinvestigativeskillswillmeetthechallengesoforalhealthresearchforthe21st century.
The aims aretopreparetraineesformeaningfulcareersinoralhealthresearchandacademicsby providingoutstandinginterdisciplinarydidactictrainingandrigorousresearchmentoringexperiences emphasizingongoingreviewandcritique.Theproposedprogramcontinuation,buildingon30+yearsof researchtrainingsuccess,hasafocusondentalgraduates,butrecognizesthatbasicscientistsalsoplay importantrolesinoralhealthresearch;?thus,itwillalsooffertrainingopportunitiesfornon-dentists.TheR90 componentreflectstheincreasinglyimportantrolethatinternationaldentistshave,andwillcontinuetohave,in ouroralhealthresearchprograms.Thefivemajorresearchareasinwhichtrainingisoffered,1) Bioengineering,TissueEngineering,StemCells,Biomaterials,andMaterialsResearch2)Immunology, Inflammation,Microbiology,Caries,andMicrobiomeResearch3)Craniofacial,OralBiology,Genetics,and DentalDevelopmentResearch4)PublicHealth,EpidemiologyandBehavioralSciences,and5)OralHealth PolicyResearch,reflectthestrengthsoftheCollegeofDentistry,thehealthsciencecolleges,UIinstitutesand centersandrangeacrossthefulltranslationalspectrum.Specifically,weoffertrainingfordentistsandnon- dentiststopursueaPhDinOralSciences(orinoneofthesixotherPhDprogramsfromwhichwewillrecruit, asappropriate),ortopursuepost-doctoraltraining.Inaddition,therewillbeanopportunitytoobtaina CertificateinTranslationalandClinicalInvestigationundertheauspicesoftheUIInstituteforClinicaland TranslationalSciences(ourCTSA-fundedinstitute).Agroupof28experiencedandtalentedprogramfaculty fromavarietyofdisciplinesisavailabletomentortrainees.Trainingwillbesupervisedbyanexperienced DirectorandAssociateDirector,assistedbyaFacultyLeadershipteam.Theprogramwillhaveinternaland externaladvisorycommittees,anewly-establishedGrant-writingCommittee,anewly-establishedFaculty MentoringProgram,andaCommitteeonRecruitmentandDiversity.Insummary,theprogrambringstogether productive,well-fundedmentorswithpre-andpost-doctoraltraineesinanenvironmentwithastrong institutionalcommitmenttodevelopoutstandinginterdisciplinaryresearchtraining,astronginstitutionalrecord oftraininginrelevantdisciplines,andexcellenteducationalandresearchfacilities.Theoutcomewillcontinue tobethedevelopmentofacadreoforalhealthresearchersequippedtofunctionatthecuttingedgeoftheir disciplines.

Public Health Relevance

The proposed continuation of our training program is designed to provide training opportunities at the PhD and post-doctoral levels for both dentist and non-dentist scientists, including training in translational and clinical research. This program is designed to allow trainees to develop the complex skills necessary to undertake independent and collaborative research, and thus to become dental scholars capable of meeting future opportunities and challenges in dental education and oral health research nationwide.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Research Training Award (T90)
Project #
2T90DE023520-06
Application #
9567668
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2013-07-01
Project End
2023-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Iowa
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Bates, Amber M; Gomez Hernandez, Maria Paula; Lanzel, Emily A et al. (2018) Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines. Transl Cancer Res 7:533-542
Ebeid, Kareem; Meng, Xiangbing; Thiel, Kristina W et al. (2018) Synthetically lethal nanoparticles for treatment of endometrial cancer. Nat Nanotechnol 13:72-81
Lansdon, Lisa A; Darbro, Benjamin W; Petrin, Aline L et al. (2018) Identification of Isthmin 1 as a Novel Clefting and Craniofacial Patterning Gene in Humans. Genetics 208:283-296
Garaicoa, Jorge L; Fischer, Carol L; Bates, Amber M et al. (2018) Promise of Combining Antifungal Agents in Denture Adhesives to Fight Candida Species Infections. J Prosthodont 27:755-762
Raina, Monica; Bates, Amber M; Fischer, Carol L et al. (2018) Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B. J Periodontol 89:361-369
Villhauer, Alissa L; Lynch, David J; Warren, John J et al. (2017) Genotypic characterization and comparison of Streptococcus mutans in American Indian and Southeast Iowa children. Clin Exp Dent Res 3:235-243
Villhauer, Alissa L; Lynch, David J; Drake, David R (2017) Improved method for rapid and accurate isolation and identification of Streptococcus mutans and Streptococcus sobrinus from human plaque samples. J Microbiol Methods 139:205-209
Li, Kun; Wohlford-Lenane, Christine L; Channappanavar, Rudragouda et al. (2017) Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci U S A 114:E3119-E3128
Wongrakpanich, Amaraporn; Morris, Angie S; Geary, Sean M et al. (2017) Surface-modified particles loaded with CaMKII inhibitor protect cardiac cells against mitochondrial injury. Int J Pharm 520:275-283
Bates, Amber M; Garaicoa, Jorge L; Fischer, Carol L et al. (2017) Diminished Antimicrobial Peptide and Antifungal Antibiotic Activities against Candida albicans in Denture Adhesive. Antibiotics (Basel) 6:

Showing the most recent 10 out of 39 publications