Quantitative approaches have a long history in the neurosciences, having contributed to the extraordinary progress made in understanding nervous system function at all levels of biological organization--from genes to behavior. Now, investigators from a variety of disciplines are beginning to incorporate engineering approaches in analyzing brain function, manipulating brain function, and building devices that duplicate or repair function lost in the injured brain. Into this rapidly evolving field of study, Yale proposes an Interdisciplinary Graduate Training Program in Neuroengineering. This proposal comes at an auspicious and important time in Yale's history: a new department of biomedical engineering was just formed, with a new research building under construction; a new center for magnetic resonance research was just opened with state-of-the-art research imaging capabilities; and the highly collaborative neuroscience community has grown to account for more than half of the university's biomedical research activity. Predoctoral students in the Neuroengineering Program would benefit from all of these institutional resources. By bringing 19 faculty members--representing 7 different departments and a large base of federally-supported individual and team grants--together in a unified training effort, the Neuroengineering program will: 1) prepare a group of scientists by full immersion in the disciplines of biomedical engineering and neuroscience; 2) create a new and vibrant interdisciplinary community at Yale; 3) develop new didactic courses and curriculum approaches for this field of study; and 4) implement a team approach for using quantitative biomedical engineering methods for solving complex problems in neuroscience. The students trained in this interdisciplinary program will be uniquely prepared to contribute to the academic and industrial workforce, and to speed progress towards diagnosis, treatment, and prevention of disease in the nervous system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Interdisciplinary Research Training Award (T90)
Project #
5T90DK070068-05
Application #
7485682
Study Section
Special Emphasis Panel (ZDK1-GRB-3 (O1))
Program Officer
Bishop, Terry Rogers
Project Start
2004-09-30
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2010-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$435,743
Indirect Cost
Name
Yale University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Fung, Edward K; Carson, Richard E (2013) Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines. Phys Med Biol 58:1903-23
Hertz, Jonathan; Robinson, Rebecca; Valenzuela, Daniel A et al. (2013) A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells. Acta Biomater 9:7622-9
Sandiego, Christine M; Nabulsi, Nabeel; Lin, Shu-Fei et al. (2013) Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys. Synapse 67:489-501
Sandiego, Christine M; Jin, Xiao; Mulnix, Tim et al. (2013) Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals. J Nucl Med 54:1962-8
Sandiego, Christine M; Weinzimmer, David; Carson, Richard E (2013) Optimization of PET-MR registrations for nonhuman primates using mutual information measures: a Multi-Transform Method (MTM). Neuroimage 64:571-81
Williams, Cicely; Rauch, Millicent Ford; Michaud, Michael et al. (2012) Short term interactions with long term consequences: modulation of chimeric vessels by neural progenitors. PLoS One 7:e53208
Cheng, Christopher J; Saltzman, W Mark (2011) Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides. Biomaterials 32:6194-203
Robinson, Rebecca; Viviano, Stephen R; Criscione, Jason M et al. (2011) Nanospheres delivering the EGFR TKI AG1478 promote optic nerve regeneration: the role of size for intraocular drug delivery. ACS Nano 5:4392-400
Lo, Catherine T; Van Tassel, Paul R; Saltzman, W Mark (2010) Poly(lactide-co-glycolide) nanoparticle assembly for highly efficient delivery of potent therapeutic agents from medical devices. Biomaterials 31:3631-42
Stockmann, Jason P; Ciris, Pelin Aksit; Galiana, Gigi et al. (2010) O-space imaging: Highly efficient parallel imaging using second-order nonlinear fields as encoding gradients with no phase encoding. Magn Reson Med 64:447-56

Showing the most recent 10 out of 22 publications