The Clinical and Translational Research Award (CTSA) has been greeted enthusiastically by the University of Pennsylvania (Penn). A strategic plan had identified clinical and translational research as a priority, leading to formation of the Institute for Translational Medicine and Therapeutics (ITMAT) in January 2005. ITMAT anticipated some aspects of the CTSA - inclusion of the GCRC, dedicated """"""""dry"""""""" and """"""""wet bench"""""""" space for translational research and a robust educational program, configured on a Masters in Translational Research (MTR). This CTSA proposal prompted intra and inter-institutional consideration of how to build on this achievement. This has forged a transformational alliance between Penn, the Children's Hospital of Philadelphia (CHOP), the Wistar Institute (Wl) and the University of the Sciences in Philadelphia (USP). Faculty from 9 of the 12 schools at Penn and from the partner institutions are represented in leadership roles in the response to this CTSA. ITMAT, designated as the """"""""academic home"""""""" for clinical and translational research, has been broadened to serve a trans-institutional role. Its structure has been transformed to foster interdisciplinary science from discovery of new molecules through to the study of drug action in large populations. This has been accomplished by developing interdisciplinary centers, related cores, innovative interdisciplinary programs of research and strategies to engage and inform communities and their physicians. A particular emphasis has been placed on training and innovative programs, which cover the entire career span, engaging undergraduate students through to mature clinicians, are proposed. These include the flexible use of the MTR and new tracks in the Masters in Clinical Epidemiology (MSCE) with the MD, PhD, VMD, MSN, DMD and MBA degrees;the set aside of places for medical school entrants pursuing MD-MTR/MSCE degrees and the flexible use of our diverse faculty tracks at Penn and CHOP to broaden physician engagement in research. These initiatives will be pursued in partnership with industry (e.g. GSK, Oracle), the State of Pennsylvania (BioAdvance), the FDA and a national network of institutions holding CTSAs. An elaborateand diversified approach to tracking the productivity of this program has been developed and will be integrated into a national plan with similar centers. In summary, this initiative has fostered (i) an integrated strategy to clinical and translational research by Penn, CHOP, the Wl and USP and (ii) the transformation of ITMAT. This will permit the development of interdisciplinary structures designed to. foster and facilitate research and education in this emerging discipline.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Training Award (TL1)
Project #
5TL1RR024133-05
Application #
7916649
Study Section
Special Emphasis Panel (ZRR1-CR-A (01))
Program Officer
Wilde, David B
Project Start
2006-09-30
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$218,672
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tolbert, Vanessa P; Coggins, Grace E; Maris, John M (2017) Genetic susceptibility to neuroblastoma. Curr Opin Genet Dev 42:81-90
Zanoni, Paolo; Khetarpal, Sumeet A; Larach, Daniel B et al. (2016) Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science 351:1166-71
Parks, Elizabeth P; Kazak, Anne; Kumanyika, Shiriki et al. (2016) Perspectives on Stress, Parenting, and Children's Obesity-Related Behaviors in Black Families. Health Educ Behav 43:632-640
Strom, Brian L; Schinnar, Rita; Karlawish, Jason et al. (2015) Statin Therapy and Risk of Acute Memory Impairment. JAMA Intern Med 175:1399-405
Quatromoni, Jon G; Singhal, Sunil; Bhojnagarwala, Pratik et al. (2015) An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. J Leukoc Biol 97:201-9
Quatromoni, Jon G; Predina, Jarrod D; Bhojnagarwala, Pratik et al. (2014) Adenoviral-based immunotherapy provides local disease control in an orthotopic murine model of esophageal cancer. J Immunother 37:283-92
Dood, Robert L; Gracia, Clarisa R; Sammel, Mary D et al. (2014) Endometrial cancer after endometrial ablation vs medical management of abnormal uterine bleeding. J Minim Invasive Gynecol 21:744-52
Quatromoni, Jon G; Suzuki, Eiji; Okusanya, Olugbenga et al. (2013) The timing of TGF-? inhibition affects the generation of antigen-specific CD8+ T cells. BMC Immunol 14:30
Guttmann, David M; Hart, Lori; Du, Kevin et al. (2013) Inhibition of Hsp27 radiosensitizes head-and-neck cancer by modulating deoxyribonucleic acid repair. Int J Radiat Oncol Biol Phys 87:168-75
Larach, Daniel B; Cuchel, Marina; Rader, Daniel J (2013) Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics. Clin Lipidol 8:635-648

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