_^ '' The Yale Center for Clinical Investigation (YCCI)was createdto provide a """"""""home""""""""for training the next generation of clinical investigators. Key programmatic goalsare to 1) attract highjy talented students and junior faculty across medicine, nursing, public health, biological sciences and biomedical engineering;and train them in the use of state-of-the-art researchtools;give them the skills to work within complexresearch teams;and support their professional development;and 2) fosterthe translation ofdisease-related discoveries fromthe laboratory into the community by: stimulating the creation of interdisciplinary teams; making available state-of-the-art core facilities andexpandedbiostatistical and bioinformaticsresources; establishing organizational and regulatory infrastructure for clinical studies;andforging a dynamicnew partnership that will integrate community leaders, physicians, and health centers. Participating institutions include the Schoolsof Medicine, Nursing, Public Health, the Department of Biomedical Engineering and Graduate Programs in Biological and Biomedical Sciences. The Investigative Medicine program (IMP) is central to YCCI's education and training efforts. It is a unique doctoral programthat offers Ph.D. degreesin Health SciencesResearch to highly qualified M.D. fellows embarkingon careers in translational or clinical research. IMPwill be expandedwith CTSAsupport to include nursing, public health, biological sciences, and MD-PhD students. YCCI has also createda Society of YCCI Faculty Mentorswho willparticipate actively in the training and nurturing of the students andjunior faculty members identified as YCCIClinical Scholars. Pilot and feasibility (P&F) grants will be awarded for. 1)junior faculty;2) interdisciplinary translational teams;3) newtechnologies;and 4) community-basedprojects. YCCIwill cluster research cores aroundcommonthemes,including: imaging;specimenanalysis;physiology;cognition and behavior; drug development;andcell therapy. A newOffice of ResearchServices will provide facilities for """"""""one-stop"""""""" shopping for regulatory, biostatistical, bioinformatics, recruitment and other support services.YCCI will have an officeto coordinatethe University's efforts to address health issuesfacing our community.The University's decision to immediately provide substantial supportto establish the YCCIreflects itsstrong commitment to an innovative redesign of our clinical andtranslational research activities.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Training Award (TL1)
Project #
5TL1RR024137-05
Application #
7940994
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Merchant, Carol
Project Start
2006-09-30
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$440,016
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Albright, Benjamin; Dhaher, Roni; Wang, Helen et al. (2017) Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition. Exp Neurol 288:122-133
Pfaff, Miles J; Xue, Ke; Li, Li et al. (2016) FGFR2c-mediated ERK-MAPK activity regulates coronal suture development. Dev Biol 415:242-250
McNeer, Nicole Ali; Anandalingam, Kavitha; Fields, Rachel J et al. (2015) Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nat Commun 6:6952
Fields, Rachel J; Quijano, Elias; McNeer, Nicole Ali et al. (2015) Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Adv Healthc Mater 4:361-6
Belman, Jonathan P; Bian, Rachel R; Habtemichael, Estifanos N et al. (2015) Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment. J Biol Chem 290:4447-63
Lu, Daniel Y; Chen, Elizabeth Y; Wong, Daniel J et al. (2014) Vein graft adaptation and fistula maturation in the arterial environment. J Surg Res 188:162-73
Andrejecsk, Jillian W; Cui, Jiajia; Chang, William G et al. (2013) Paracrine exchanges of molecular signals between alginate-encapsulated pericytes and freely suspended endothelial cells within a 3D protein gel. Biomaterials 34:8899-908
Thomas, Marc D; Pfaff, Miles J; Tonn, Janelle et al. (2013) Normal nasolabial anatomy in infants younger than 1 year of age. Plast Reconstr Surg 131:574e-81e
Pfaff, Miles J; Bickerton, Shixin; DiLuna, Michael et al. (2013) Transcranial nasoethmoidal dermoids: a review and rationale for approach. J Plast Reconstr Aesthet Surg 66:1725-31
Eid, Tore; Tu, Nathan; Lee, Tih-Shih W et al. (2013) Regulation of astrocyte glutamine synthetase in epilepsy. Neurochem Int 63:670-81

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