Abstract

After a successful and highly productive first grant period, the Oregon Clinical and Translational Research Institute (OCTRI) is well positioned to have greater impact in the next grant period. OCTRI's goals are:
Specific Aim 1. Generate sustained OHSU and KPCHR research growth and productivity across the spectrum of translational science.
Specific Aim 2. Translate new biomedical knowledge into widespread advances in human health and healthcare reform.
Specific Aim 3. Create a regional consortium for clinical and translational research.
Specific Aim 4. Expand the impact ofthe strong OCTRI educational curriculum, develop an institution-wide, coordinated career development process that builds on the strengths of existing programs, and extend it throughout the region and nationally.
Specific Aim 5. Enhance key infrastructure programs to support local and regional clinical and translational research. These plans will build on major progress during the first grant period to further expand clinical and translational research, career development and benefits to human health. OCTRI will utilize a series of innovative partnerships to leverage CTSA support, expand its extensive collaborations with communities, and take advantage of a regional consortium of academic institutions working together to enhance translation. As a member of the CTSA Consortium, OCTRI will contribute unique expertise and resources to the combined effort to solve biomedical problems. Oregon Health and Science University and its partner institution Kaiser Permanente Center for Health Research have committed strong leadership support and substantial institutional commitment to OCTRI's continued mission.

Public Health Relevance

OCTRI will have a major influence on clinical and translational research at OHSU and KPCHR, and will increase their contributions to biomedical discovery. As the only academic medical center in Oregon, OHSU has a unique opportunity to catalyze translational research growth on a regional scale. Via its participation in the CTSA Consortium, OCTRI will advance national research productivity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Training Award (TL1)
Project #
2TL1RR024159-06
Application #
8233617
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Talbot, Bernard
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$153,252
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Klug, Lillian R; Bannon, Amber E; Javidi-Sharifi, Nathalie et al. (2018) LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma. Oncogene :
Bergstrom, Colin P; Geest, Koen De; O'Gara, Rebecca et al. (2016) Discordant Mutations in Paired Primary and Metastatic Endometrial Adenocarcinomas Identified by Semiconductor-Based Sequencing for Rapid Cancer Genotyping. Reprod Sci 23:1575-1579
Meurer, William J; Quinn, James; Lindsell, Christopher et al. (2016) Emergency Medicine Resources Within the Clinical Translational Science Institutes: A Cross-sectional Study. Acad Emerg Med 23:740-3
Tullis, Brandon E; Ryals, Renee C; Coyner, Aaron S et al. (2015) Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci 56:4560-9
Javidi-Sharifi, Nathalie; Traer, Elie; Martinez, Jacqueline et al. (2015) Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance. Cancer Res 75:880-91
Gilbert, Kenneth; Joseph, Raphael; Vo, Alex et al. (2014) Children with severe early childhood caries: streptococci genetic strains within carious and white spot lesions. J Oral Microbiol 6:
Meserve, Emily; Berlin, Michelle; Mori, Tomi et al. (2014) Reducing misclassification bias in cervical dysplasia risk factor analysis with p16-based diagnoses. J Low Genit Tract Dis 18:266-72
Liu, Betty Y; O'Malley, Jean; Mori, Motomi et al. (2014) The association of type and number of chronic diseases with breast, cervical, and colorectal cancer screening. J Am Board Fam Med 27:669-81
Williams, Sarah; Gregory, Allison; Hogarth, Penelope et al. (2013) Metabolism and energy requirements in pantothenate kinase-associated neurodegeneration. Mol Genet Metab 110:336-41
Palmer, Elizabeth A; Nielsen, Truman; Peirano, Patricia et al. (2012) Children with severe early childhood caries: pilot study examining mutans streptococci genotypic strains after full-mouth caries restorative therapy. Pediatr Dent 34:e1-10

Showing the most recent 10 out of 21 publications