This revised application for a Clinical and Translational Science Award (CTSA) would support the continued development of the Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision Is to improve health of the diverse and underserved population of urban Los Angeles and. In doing so, to gain knowledge that we can share with others to Improve health In urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: build on many independent strengths to create an integrated academic home that places high priority on clinical and translational science;create new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorities of our local communities;transform education and training to create a cadre of people with a major career focus on clinical and translational research;and implement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: outstanding resources for active development of new research projects and teams, a robust infrastructure to promote and support basic, clinical and community research, cutting edge methodologies for data acquisition, integration, management and analysis;integrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities;a novel approach to dissemination of our findings using professional communications expertise;and a professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translational research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Training Award (TL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Sufian, Meryl
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Angell, Amber M; Solomon, Olga (2018) Understanding parents' concerns about their children with autism taking public school transportation in Los Angeles County. Autism 22:401-413
Doyle, Eamon K; Toy, Kristin; Valdez, Bertin et al. (2018) Ultra-short echo time images quantify high liver iron. Magn Reson Med 79:1579-1585
Siantz, Elizabeth; Rice, Eric; Henwood, Benjamin et al. (2018) Where do Peer Providers Fit into Newly Integrated Mental Health and Primary Care Teams? A Mixed Method Study. Adm Policy Ment Health 45:538-549
Siantz, Elizabeth; Henwood, Benjamin; Baezcondi-Garbanati, Lourdes (2018) From Physical Wellness to Cultural Brokering: Unpacking the Roles of Peer Providers in Integrated Health Care Settings. Community Ment Health J 54:1127-1135
Angell, Amber M; Solomon, Olga (2017) 'If I was a different ethnicity, would she treat me the same?': Latino parents' experiences obtaining autism services. Disabil Soc 32:1142-1164
Siantz, Elizabeth; Wu, Brian; Shiroishi, Mark et al. (2017) Mental Illness Is Not Associated with Adherence to Colorectal Cancer Screening: Results from the California Health Interview Survey. Dig Dis Sci 62:224-234
Skeate, Joseph G; Porras, Tania B; Woodham, Andrew W et al. (2016) Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection. J Gen Virol 97:422-34
Pulido, Mario A; DerHartunian, Meleeneh Kazarian; Sehgal, Prerna et al. (2016) Data on isoaspartylation of neuronal ELAVL proteins. Data Brief 9:1052-1055
Agnello, Melissa; Finkel, Steven E; Wong-Beringer, Annie (2016) Fitness Cost of Fluoroquinolone Resistance in Clinical Isolates of Pseudomonas aeruginosa Differs by Type III Secretion Genotype. Front Microbiol 7:1591
Woodham, Andrew W; Yan, Lisa; Skeate, Joseph G et al. (2016) T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation. Papillomavirus Res 2:21-30

Showing the most recent 10 out of 34 publications