The Indiana Clinical and Translational Sciences Institute (CTSI) was created in 2008 at the crest of a wave of transformation of ttie three research universities in Indiana and has become a flagship catalyst for the state's biomedical initiatives. The mission of the Indiana CTSI is to be an integrated home for clinical and translational research that creates a shared, investigator-friendly institutional environment and provides easily accessible resources, services, and training td conduct the highest-quality research dedicated to improving human health across Indiana and beyond. The Four Specific Aims of the Indiana CTSI are:
Aim I. Implement an Indiana roadmap for building,the ideal research environment and collaborative platforms to conduct innovative research using our excellent multi-institutional, public-private partnerships throughout the state of Indiana and beyond by bringing together all three major research universities, Indiana, Purdue and Notre Dame, the state's key health care provider partners, private sector and corporate entities, and local and state agencies to create the infrastructure.
Aim II. Further develop our successful Indiana CTSI established with the previous award into an """"""""integrated home"""""""" that supports the careers and research projects of translational scientists and trainees through a streamlined structure, empowered leadership and administration, coordinated partner institution resources, robust informatics infrastructure, innovative project development teams, and continuous evaluation and process improvement.
Aim III. Promote utilization of our innovative services arjid a well-tested network of resources and technologies in order to catalyze high-quality, efficient, and safe clinical and translational research. We have created Project Assistance and Resources for Translational Scientists (PARTS) suite of both established and new research support services and resources, a statewide network of technology cores, and a coordinated human subject research services and facilities.
Aim I V. Extend our success in statewide education and training of clinical and translational research workforce th'rough our Career development, Education and Research Training (CERT) suite of programs that includes successful existing programs, new training programs, and novel educational tools.

Public Health Relevance

; The Indiana Clinical and Translational Sciences Institute (CTSI) was created in 2008 as a statewide institute by the partnership of three research universities in Indiana (Indiana, Purdue and Notre Dame) and has become an essential resource for the state's biomedical initiatives. Here we describe its innovative vision, its impact, and its success in creating public-private partnerships to benefit the health and economy of the state.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR001107-02
Application #
8743350
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Wilson, Todd
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Klymenko, Yuliya; Wates, Rebecca B; Weiss-Bilka, Holly et al. (2018) Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates. Dis Model Mech 11:
Riley, Timothy P; Hellman, Lance M; Gee, Marvin H et al. (2018) T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability. Nat Chem Biol 14:934-942
Dahlgren, Paige N; Bishop, Kanokwan; Dey, Shatovisha et al. (2018) Development of a New Monochrome Multiplex qPCR Method for Relative Telomere Length Measurement in Cancer. Neoplasia 20:425-431
Castellanos, Irina; Kronenberger, William G; Pisoni, David B (2018) Psychosocial Outcomes in Long-Term Cochlear Implant Users. Ear Hear 39:527-539
Frump, Andrea L; Selej, Mona; Wood, Jordan A et al. (2018) Hypoxia Upregulates Estrogen Receptor ? in Pulmonary Artery Endothelial Cells in a HIF-1?-Dependent Manner. Am J Respir Cell Mol Biol 59:114-126
Hunter, Cynthia R; Pisoni, David B (2018) Extrinsic Cognitive Load Impairs Spoken Word Recognition in High- and Low-Predictability Sentences. Ear Hear 39:378-389
Schnepp, Patricia M; Lee, Dennis D; Guldner, Ian H et al. (2017) GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment. Cancer Res 77:2844-2856
McGregor, Kyle A; Hensel, Devon J; Waltz, Amy C et al. (2017) Adolescent Sexual Behavior Research: Perspectives of Investigators, IRB Members, and IRB Staff about Risk Categorization and IRB Approval. IRB 39:17-20
Quinn, Patrick D; Chang, Zheng; Hur, Kwan et al. (2017) ADHD Medication and Substance-Related Problems. Am J Psychiatry 174:877-885
Allette, Yohance M; Kim, Youngsook; Randolph, Aaron L et al. (2017) Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons. Sci Rep 7:3741

Showing the most recent 10 out of 43 publications