To fulfill the new NCATS vision for the CTSA Consortium and accelerate scientific discoveries into improved outcomes for patients, academic health and science systems must invest, transform, and innovate to optimize their unique strengths. Our vision, aligned with that of NCATS, is to create a research environment at Duke that stimulates the translation of scientific discovery from bench to bedside by 1) linking discovery science to a creative engine that efficiently accelerates development of new technologies;and 2) integrating clinical trials, registries, and electronic health records in a learning health system where research and practice form a continuum. Our research environment will be driven by scientific merit and societal need, """"""""agnostic"""""""" to disease or specialty discipline, aligned with our updated institutional framework for research oversight and quality, and continually evaluated for academic productivity, efficiency, and cost. To achieve these goals, we will create an Integrated Home for clinical and translational research by providing infrastructure and resources to serve investigators and trainees across the research spectrum. We will offer resources based upon common needs among our researchers, including education, biostatistics, biobanking, regulatory expertise, ethics, pilot funding and recruitment assistance. We will also tailor our offerings to specialized needs across research communities that include early translation, proof of concept, site-based research and population based research, which includes multi-site trials, outcomes, health services, implementation science and community engaged research. Integrating these resources will require a new tool, a portal for all trainees and investigators, MyResearchHome(@Duke, and its human counterpart, MyResearchTeam@Duke. These tools will provide a single point of entry for all clinical and translational research at Duke, regardless of their department or school. Thus, we will enhance our Integrated Home for clinical and translational research with a combination of sophisticated information technology and mentoring and navigation;provide access to common and specialized resources for all of our translational research communities and train the next generation of researchers in our educational and training programs.

Public Health Relevance

The CTSA will foster the translational research process, ensuring that new discoveries are developed and evaluated more quickly and that clinical research is done with high quality, efficiency, safety and cost- effectiveness.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Training Award (TL1)
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Special Emphasis Panel (ZAI1-PTM-C (S1))
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Sufian, Meryl
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Duke University
Internal Medicine/Medicine
Schools of Medicine
United States
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Campbell, Kathleen; Carpenter, Kimberly Lh; Hashemi, Jordan et al. (2018) Computer vision analysis captures atypical attention in toddlers with autism. Autism :1362361318766247
Andrew, Benjamin Y; Andrew, Elias Y; Cherry, Anne D et al. (2018) Intraoperative Renal Resistive Index as an Acute Kidney Injury Biomarker: Development and Validation of an Automated Analysis Algorithm. J Cardiothorac Vasc Anesth 32:2203-2209
Cunningham, Daniel; Lewis, Brian; Hutyra, Carolyn et al. (2018) Prospective, Observational Study of Opioid Use After Hip Arthroscopy for Femoroacetabular Impingement Syndrome. Arthroscopy 34:1488-1497.e6
Andrew, Benjamin Y; Cherry, Anne D; Hauck, Jennifer N et al. (2018) The Association of Aortic Valve Pathology With Renal Resistive Index as a Kidney Injury Biomarker. Ann Thorac Surg 106:107-114
Gopalakrishna, Ajay; Chang, Andrew; Longo, Thomas A et al. (2018) Dietary patterns and health-related quality of life in bladder cancer survivors. Urol Oncol 36:469.e21-469.e29
Hunter, Wynn G; Zafar, S Yousuf; Hesson, Ashley et al. (2017) Discussing Health Care Expenses in the Oncology Clinic: Analysis of Cost Conversations in Outpatient Encounters. J Oncol Pract 13:e944-e956
Chapurin, Nikita; Pynnonen, Melissa A; Roberts, Rhonda et al. (2017) CHEER National Study of Chronic Rhinosinusitis Practice Patterns: Disease Comorbidities and Factors Associated with Surgery. Otolaryngol Head Neck Surg 156:751-756
de Jong, Marrigje A; Carpenter, David J; Kaylie, David M et al. (2017) Temporal bone anatomy characteristics in superior semicircular canal dehiscence. J Otol 12:185-191
Gopalakrishna, Ajay; Longo, Thomas A; Fantony, Joseph J et al. (2017) Physical activity patterns and associations with health-related quality of life in bladder cancer survivors. Urol Oncol 35:540.e1-540.e6
Brown, Gregory D; Hunter, Wynn G; Hesson, Ashley et al. (2017) Discussing Out-of-Pocket Expenses During Clinical Appointments: An Observational Study of Patient-Psychiatrist Interactions. Psychiatr Serv 68:610-617

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