This is an application for an institutional training grant in translational biomedical science (TBS) that is a component of the clinical translational science award application submitted by Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS), which is comprised of Georgetown University (GU) Medical Center (GUMC) and Howard University (HU) College of Medicine (HUCM) and the GHUCCTS partnering institutions, MedStar Health Research Institute (MHRI) and the Washington, DC Veterans Administration (VA). We request support for 10 trainee positions a year for advanced predoctoral students and/or postdoctoral fellows in their first or second year of training. The goal of this program is to train predoctoral students and postdoctoral fellows to become a critical link between preclinical and clinical research in the job market including academia, government and industry and thereby serve as the next generation of investigators who will advance the translation of basic science into improved outcomes for human health. Trainees enjoy dual mentorship in basic science and clinical research from the 88 TBS faculty within GHUCCTS at GU (59), HU (20), MHRI (1), the VA (7) and one from NIH of which 68 are Core and 20 are Center Faculty. The trainee along with their preclinical and clinical mentors in conjunction with the TBS Executive Committee and the TBS Internal Advisory Committee (IAC) will design the trainee's Career Development Plan (CDP), which includes five components: 1) didactic education in human health- and disease-related aspects including technical skill development and rigorous research methodology; 2) experiential learning in clinical medicine through mentored rotations on clinical committees and exposure to clinical medicine through mentored rotations in out-patient or community-based clinics and/or in-patient service; 3) research training in preclinical and clinical research via dual mentorship; 4) training in leadership skills including team science, communication, networking, negotiation, and time management; and, 5) individualized career guidance and acquisition of career-specific skills. The CDP is tailored to an individual?s prior background and experience, and current interests and trainee progress is monitored and evaluated through the trainee Trainee Monitoring Plan. Program performance is evaluated at several levels including through the Executive Committee (EXCO), Internal and External Advisory Committees (IAC & EAC) and ultimately through data collected by the TBS Alumni organization.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
3TL1TR001431-02S1
Application #
9395144
Study Section
Program Officer
Brazhnik, Olga
Project Start
2015-08-28
Project End
2020-03-31
Budget Start
2016-12-21
Budget End
2017-03-31
Support Year
2
Fiscal Year
2017
Total Cost
$8,474
Indirect Cost
$552
Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Pai, Amrita V; Maddox, Taylor; Sandberg, Kathryn (2018) T Cells and Hypertension: Solved and Unsolved Mysteries Regarding the Female Rat. Physiology (Bethesda) 33:254-260
de Souza, Aline Maria Arlindo; West, Crystal A; de Abreu, Aline Rezende Ribeiro et al. (2018) Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats. Sci Rep 8:10327
Colie, Christine; Michel, Katherine G; Massad, Leslie S et al. (2018) Natural History of Cervical Intraepithelial Neoplasia-2 in HIV-Positive Women of Reproductive Age. J Acquir Immune Defic Syndr 79:573-579
Sun, Zhi Yong; Bozzelli, P Lorenzo; Caccavano, Adam et al. (2018) Disruption of perineuronal nets increases the frequency of sharp wave ripple events. Hippocampus 28:42-52
Burks, Julian; Nadella, Sandeep; Mahmud, Abdullah et al. (2018) Cholecystokinin Receptor-Targeted Polyplex Nanoparticle Inhibits Growth and Metastasis of Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 6:17-32
Lelo, Alana; Prip, Frederik; Harris, Brent T et al. (2018) STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non-Muscle-Invasive Bladder Cancer. Clin Cancer Res 24:4145-4153
Kobayashi, Ihori; Howell, Mary Katherine (2018) Impact of Traumatic Stress on Sleep and Management Options in Women. Sleep Med Clin 13:419-431
Jiang, Huiyi; Liu, Shicheng; Geng, Xinling et al. (2018) Pacing Hippocampal Sharp-Wave Ripples With Weak Electric Stimulation. Front Neurosci 12:164
Smith, Jill P; Wang, Shangzi; Nadella, Sandeep et al. (2018) Cholecystokinin receptor antagonist alters pancreatic cancer microenvironment and increases efficacy of immune checkpoint antibody therapy in mice. Cancer Immunol Immunother 67:195-207
da Cruz, Raquel Santana; Carney, Elissa J; Clarke, Johan et al. (2018) Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring. Breast Cancer Res 20:99

Showing the most recent 10 out of 25 publications