The goal of the Washington University (WU) TL1 Training Program is to develop a professional translational workforce through mentored clinical and translational research (CTR) experiences, competency-based coursework, and personalized training for predoctoral trainees and postdoctoral fellows. Trainees are drawn from diverse disciplines at WU and our Institute of Clinical and Translational Science (ICTS) partners - University of Missouri-Columbia, Saint Louis University, St. Louis College of Pharmacy, and Goldfarb School of Nursing. We are requesting support for 10 predocs and 10 postdocs for 1-3 years. To enhance our highly successful TL1, we propose the following Aims: 1. Promote translational science workforce development by providing outstanding predoctoral and post-doctoral clinical and T1-T4 translational research training. WORKFORCE DEVELOPMENT 2. Develop tailored learning opportunities for trainees interested in T1-T4 CTR and diversify programmatic opportunities to include an emphasis on interdisciplinary professional skill training. We will provide competency-based, individualized development plans, online (on-demand) coursework, externships, and community engagement opportunities for trainees from multiple disciplines. New externships in dissemination and implementation, entrepreneurship, innovation, and commercialization will diversify TL1 programmatic opportunities. INTEGRATION 3. Implement innovative methods for tracking and evaluation of TL1 programs, trainees, and alumna and use this data for program improvement and to measure the changing culture of ICTS research teams. We will implement the TL1 Evaluation Logic Model, a tool-based analytic approach, to evaluate engagement in, understanding of, and satisfaction with programmatic offerings. METHODS & PROCESSES 4. Increase interactions between the TL1 faculty, trainees, and fellows with stakeholders, other ICTS functions, ICTS partners, and CTSA hubs. We will leverage resources, share best practices, and create learning communities across disciplines to foster patient and community-centered translational research and training at local, regional, and national levels. COLLABORATION & ENGAGEMENT 5. Provide high-quality, comprehensive informatics training. Through the new WU Institute for Informatics and our ICTS partners, we will offer new courses, certificates and degree programs in Informatics. We will integrate informatics methods, tools, and skills into all of our courses and training programs. INFORMATICS Completion of these aims will result in increased numbers of diverse, well-trained investigators who will lead multidisciplinary teams. Consistent with national CTSA goals, successful completion of our goals will expand the workforce of MDs, PhDs, MD/PhDs, and DVMs equipped with high-quality CTR training that can advance discovery science through the translational spectrum to improve human health.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR002344-05
Application #
10123031
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Gannot, Gallya
Project Start
2017-06-19
Project End
2022-02-28
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
5
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Self, Wade K; Schoch, Kathleen M; Alex, Jacob et al. (2018) Protein production is an early biomarker for RNA-targeted therapies. Ann Clin Transl Neurol 5:1492-1504
Han, Rowland H; McKinnon, Andrew; CreveCoeur, Travis S et al. (2018) Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study. Childs Nerv Syst :
Beleckas, Casey M; Prather, Heidi; Guattery, Jason et al. (2018) Anxiety in the orthopedic patient: using PROMIS to assess mental health. Qual Life Res :
Duncavage, Eric J; Jacoby, Meagan A; Chang, Gue Su et al. (2018) Mutation Clearance after Transplantation for Myelodysplastic Syndrome. N Engl J Med 379:1028-1041
Gnanapradeepan, Keerthana; Basu, Subhasree; Barnoud, Thibaut et al. (2018) The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis. Front Endocrinol (Lausanne) 9:124
Stepan, Jeffrey G; London, Daniel A; Osei, Daniel A et al. (2018) Perioperative Celecoxib and Postoperative Opioid Use in Hand Surgery: A Prospective Cohort Study. J Hand Surg Am 43:346-353
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3:
Lin, Jonathan B; Kubota, Shunsuke; Mostoslavsky, Raul et al. (2018) Role of Sirtuins in Retinal Function Under Basal Conditions. Adv Exp Med Biol 1074:561-567
Nikitas, John; DeWees, Todd; Rehman, Sana et al. (2018) Stereotactic Body Radiotherapy for Early-Stage Multiple Primary Lung Cancers. Clin Lung Cancer :
Lin, Jonathan B; Apte, Rajendra S (2018) NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies. Prog Retin Eye Res 67:118-129

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