Core- Virology Laboratory

Linnemann, Calvin Jr

Abstract

This is a proposal to establish a Virology Core Laboratory for the AIDS Clinical Trials Group (ACTG) at the Clinical Virology Laboratory (CVL) at the University of Cincinnati. CVL, fully certified by the Virology Reference Laboratory (VRL) of the ACTG, will continue to serve as the Virology Laboratory at the University of Cincinnati AIDS Clinical Trials Unit, including the Pediatric Subunit at the Children's Hospital Medical Center and the Cincinnati Veteran's Administration Medical Center subunit, forming all protocol mandated virology studies for these units. In addition, utilizing the CVL's resources as a large diagnostic laboratory, we will perform at least 500 HIV cultures and 2,600 P24 antigen determinations on an annual basis. The CVL is geographically located in an area that is underserved by the ACTU and does not have other ACTU viral laboratories with extensive experience with HIV virologic techniques and strong records of VRL certification.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project--Cooperative Agreements (U01)
• Project #: 5U01AI025897-08
• Application #: 3727040
• Support Year: 8
• Fiscal Year: 1995

Institution

• Name: University of Cincinnati
• City: Cincinnati
• State: OH
• Country: United States
• Zip Code: 45221

Publications

Grady, Benjamin J; Torstenson, Eric S; McLaren, Paul J et al. (2011) Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pac Symp Biocomput :253-64

Sherman, Kenneth E; Rouster, Susan D; Stanford, Sandra et al. (2010) Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens. J Infect Dis 201:712-9

Bhattacharya, Debika; Umbleja, T; Carrat, F et al. (2010) Women experience higher rates of adverse events during hepatitis C virus therapy in HIV infection: a meta-analysis. J Acquir Immune Defic Syndr 55:170-5

Zhao, Yu; Navia, Bradford A; Marra, Christina M et al. (2010) Memantine for AIDS dementia complex: open-label report of ACTG 301. HIV Clin Trials 11:59-67

Fichtenbaum, Carl J; Yeh, Tzu-Min; Evans, Scott R et al. (2010) Treatment with pravastatin and fenofibrate improves atherogenic lipid profiles but not inflammatory markers in ACTG 5087. J Clin Lipidol 4:279-87

Winham, Stacey J; Slater, Andrew J; Motsinger-Reif, Alison A (2010) A comparison of internal validation techniques for multifactor dimensionality reduction. BMC Bioinformatics 11:394

Butt, Adeel A; Tsevat, Joel; Leonard, Anthony C et al. (2009) Effect of race and HIV co-infection upon treatment prescription for hepatitis C virus. Int J Infect Dis 13:449-55

Tsevat, Joel; Leonard, Anthony C; Szaflarski, Magdalena et al. (2009) Change in quality of life after being diagnosed with HIV: a multicenter longitudinal study. AIDS Patient Care STDS 23:931-7

Skowron, Gail; Spritzler, John G; Weidler, Jodi et al. (2009) Replication capacity in relation to immunologic and virologic outcomes in HIV-1-infected treatment-naive subjects. J Acquir Immune Defic Syndr 50:250-8

Cohn, Susan E; Umbleja, Triin; Mrus, Joseph et al. (2008) Prior illicit drug use and missed prenatal vitamins predict nonadherence to antiretroviral therapy in pregnancy: adherence analysis A5084. AIDS Patient Care STDS 22:29-40