Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI026049-08
Application #
2063205
Study Section
Special Emphasis Panel (SRC (50))
Project Start
1988-04-01
Project End
1996-12-31
Budget Start
1994-04-01
Budget End
1996-12-31
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Associated University-Brookhaven National Lab
Department
Type
DUNS #
City
Upton
State
NY
Country
United States
Zip Code
11973
McGrath, William J; Aherne, Katharine S; Mangel, Walter F (2002) In the virion, the 11-amino-acid peptide cofactor pVIc is covalently linked to the adenovirus proteinase. Virology 296:234-40
Ding, J; McGrath, W J; Sweet, R M et al. (1996) Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor. EMBO J 15:1778-83
Brown, M T; McGrath, W J; Toledo, D L et al. (1996) Different modes of inhibition of human adenovirus proteinase, probably a cysteine proteinase, by bovine pancreatic trypsin inhibitor. FEBS Lett 388:233-7
McGrath, W J; Abola, A P; Toledo, D L et al. (1996) Characterization of human adenovirus proteinase activity in disrupted virus particles. Virology 217:131-8
Mangel, W F; Toledo, D L; Brown, M T et al. (1996) Characterization of three components of human adenovirus proteinase activity in vitro. J Biol Chem 271:536-43
McGrath, W J; Ding, J; Sweet, R M et al. (1996) Preparation and crystallization of a complex between human adenovirus serotype 2 proteinase and its 11-amino-acid cofactor pVIc. J Struct Biol 117:77-9
Haque, R; Neville, L M; Hahn, P et al. (1995) Rapid diagnosis of Entamoeba infection by using Entamoeba and Entamoeba histolytica stool antigen detection kits. J Clin Microbiol 33:2558-61
Anderson, C W (1993) Expression and purification of the adenovirus proteinase polypeptide and of a synthetic proteinase substrate. Protein Expr Purif 4:8-15
Freimuth, P; Anderson, C W (1993) Human adenovirus serotype 12 virion precursors pMu and pVI are cleaved at amino-terminal and carboxy-terminal sites that conform to the adenovirus 2 endoproteinase cleavage consensus sequence. Virology 193:348-55
Harber, J J; Bradley, J; Anderson, C W et al. (1991) Catalysis of poliovirus VP0 maturation cleavage is not mediated by serine 10 of VP2. J Virol 65:326-34

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