Abstract

This program has been formulated in response to the NIAID request for an Asthma and Allergic Disease Cooperative Disease Center by a team of investigators at UCSD Medical School with expertise in both clinical and basic research of allergic diseases. The proposal consist of an educational and demonstration program and four basic research projects involving cells from patients with asthma and other allergic disorders. The basic research focuses on the role of cytokines in IgE regulation and allergic inflammation and the effects of mast cell mediators on the function of endothelial cells, airway epithelial cells and keratinocytes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI031595-03
Application #
2066583
Study Section
Special Emphasis Panel (SRC (86))
Project Start
1991-09-01
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1995-08-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Ries, A L; Picchi, M A; Nguyen, L H et al. (1997) Asthma in a Vietnamese refugee population. Am J Respir Crit Care Med 155:1895-901
Lindsey, J D; Kashiwagi, K; Boyle, D et al. (1996) Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells. Curr Eye Res 15:869-75
Roth, R; Spiegelberg, H L (1996) Activation of cloned human CD4+ Th1 and Th2 cells by blood dendritic cells. Scand J Immunol 43:646-51
Weinberger, M S; Davidson, T M; Broide, D H (1996) Differential expression of vascular cell adhesion molecule mRNA and protein in nasal mucosa in response to IL-1 or tumor necrosis factor. J Allergy Clin Immunol 97:662-71
Sullivan, S; Broide, D H (1996) Compartmentalization of eosinophil granulocyte-macrophage colony-stimulating factor expression in patients with asthma. J Allergy Clin Immunol 97:966-76
Beck, L; Roth, R; Spiegelberg, H L (1996) Comparison of monocytes and B cells for activation of human T helper cell subsets. Clin Immunol Immunopathol 78:56-60
Anderson, W H; Davidson, T M; Broide, D H (1996) Mast cell TNF mRNA expression in nasal mucosa demonstrated by in situ hybridization: a comparison of mast cell detection methods. J Immunol Methods 189:145-55
Baker, J R; Kylstra, T A; Bigby, T D (1995) Effects of metalloproteinase inhibitors on leukotriene A4 hydrolase in human airway epithelial cells. Biochem Pharmacol 50:905-12
Ferguson, P; Broide, D H (1995) Environmental and bronchoalveolar lavage Dermatophagoides pteronyssinus antigen levels in atopic asthmatics. Am J Respir Crit Care Med 151:71-4
Nguyen, D D; Beck, L; Spiegelberg, H L (1995) Anti-CD3-induced anergy in cloned human Th0, Th1, and Th2 cells. Cell Immunol 165:153-7

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