Heterocyclic Dications as Anti-Opportunistic Infection Agents

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project--Cooperative Agreements (U01)
• Project #: 5U01AI033363-03
• Application #: 3747393
• Support Year: 3
• Fiscal Year: 1994

Institution

• Name: University of North Carolina Chapel Hill
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Christopher, L J; Fletcher, L D; Dykstra, C C (1995) Cloning and identification of Arp1, an actin-related protein from Pneumocystis carinii. J Eukaryot Microbiol 42:142-9

Fletcher, L D; McDowell, J M; Tidwell, R R et al. (1994) Structure, expression and phylogenetic analysis of the gene encoding actin I in Pneumocystis carinii. Genetics 137:743-50

Weinberg, G A; Dykstra, C C; Durant, P J et al. (1994) Chromosomal localization of 20 genes to five distinct pulsed field gel karyotypic forms of rat Pneumocystis carinii. J Eukaryot Microbiol 41:117S

Fletcher, L D; Berger, L C; Tidwell, R R et al. (1993) Cloning and characterization of the calmodulin-encoding gene from Pneumocystis carinii. Gene 129:307-8

Tidwell, R R; Jones, S K; Naiman, N A et al. (1993) Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother 37:1713-6

Bell, C A; Dykstra, C C; Naiman, N A et al. (1993) Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition. Antimicrob Agents Chemother 37:2668-73