Abstract

This is the renewal of the Women and Infants Transmission Study at the University of Puerto Rico, Medical Sciences Campus. In this third period of funding, the applicants state that their main objectives are to continue the development of abstracts and the advancement of sub-studies. Additionally, they expect to fortify the site at Ponce, in coordination with the Department of Health officials of the region. The catchment area has already been expanded island wide. They state that their WITS has been successful in complying with all the protocol and subprotocol requirements. They have a cumulative enrollment of 320 women and 261 infants. Puerto Rico is the site with the largest number of women and infant pairs, as well as a site with an excellent retention rate. The implementation of an Interdisciplinary Intervention Model constituted by the investigators, nurses, coordinator, administrative staff, physicians and social workers has been successful in maintaining the mother-infant binomial as a unit for continuous follow-up. The investigators state that they have been participating in the WITS since the beginning, showing a remarkable capacity in the implementation of all protocol requirements. They have the capability to continue enrolling and retaining an increasing number of pregnant women annually. The WITS in Puerto Rico is highly committed to closely link our cohorts to perinatal ACTU studies as well as pediatric ACTU projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI034858-07
Application #
2886874
Study Section
Special Emphasis Panel (ZAI1-MSQ-A (M1))
Program Officer
Hoff, Rodney
Project Start
1993-07-01
Project End
2001-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Puerto Rico Med Sciences
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00936

  Publications

Ouyang, David W; Brogly, Susan B; Lu, Ming et al. (2010) Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals. AIDS 24:109-14
Paredes, Roger; Cheng, Irene; Kuritzkes, Daniel R et al. (2010) Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy. AIDS 24:45-53
Mekmullica, Jutarat; Brouwers, Pim; Charurat, Manhattan et al. (2009) Early immunological predictors of neurodevelopmental outcomes in HIV-infected children. Clin Infect Dis 48:338-46
Watts, D H; Lu, M; Thompson, B et al. (2009) Treatment interruption after pregnancy: effects on disease progression and laboratory findings. Infect Dis Obstet Gynecol 2009:456717
Ouyang, David W; Shapiro, David E; Lu, Ming et al. (2009) Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure. AIDS 23:2425-30
Aldrovandi, Grace M; Chu, Clara; Shearer, William T et al. (2009) Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics 124:e1189-97
Dowd, Kimberly A; Hershow, Ronald C; Yawetz, Sigal et al. (2008) Maternal neutralizing antibody and transmission of hepatitis C virus to infants. J Infect Dis 198:1651-5
Pahwa, Savita; Read, Jennifer S; Yin, Wanrong et al. (2008) CD4+/CD8+ T cell ratio for diagnosis of HIV-1 infection in infants: Women and Infants Transmission Study. Pediatrics 122:331-9
Chen, Katherine T; Tuomala, Ruth E; Chu, Clara et al. (2008) No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission. Am J Obstet Gynecol 198:399.e1-5
Mellins, C A; Chu, C; Malee, K et al. (2008) Adherence to antiretroviral treatment among pregnant and postpartum HIV-infected women. AIDS Care 20:958-68

Showing the most recent 10 out of 55 publications