Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI038249-02
Application #
2075231
Study Section
Special Emphasis Panel (SRC (86))
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alberta
Department
Type
DUNS #
City
Edmonton
State
AB
Country
Canada
Zip Code
T6 2-E1
Lall, Manjinder S; Jain, Rajendra P; Vederas, John C (2004) Inhibitors of 3C cysteine proteinases from Picornaviridae. Curr Top Med Chem 4:1239-53
Ramtohul, Yeeman K; James, Michael N G; Vederas, John C (2002) Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase. J Org Chem 67:3169-78
Lall, Manjinder S; Ramtohul, Yeeman K; James, Michael N G et al. (2002) Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. J Org Chem 67:1536-47
Khan, A R; Khazanovich-Bernstein, N; Bergmann, E M et al. (1999) Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors. Proc Natl Acad Sci U S A 96:10968-75
Huang, Y; Malcolm, B A; Vederas, J C (1999) Synthesis and testing of azaglutamine derivatives as inhibitors of hepatitis A virus (HAV) 3C proteinase. Bioorg Med Chem 7:607-19
Lall, M S; Karvellas, C; Vederas, J C (1999) Beta-lactones as a new class of cysteine proteinase inhibitors: inhibition of hepatitis A virus 3C proteinase by N-Cbz-serine beta-lactone. Org Lett 1:803-6
Morris, T S; Frormann, S; Shechosky, S et al. (1997) In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketone. Bioorg Med Chem 5:797-807