The Brown University/Lifespan Adult Therapeutic Clinical Trials Application for AIDS Research brings together clinicians and researchers with expertise in clinical trials with a strong record in specific issues regarding HIV-infected women and """"""""hard to reach populations"""""""". This is an unaffiliated clinical trials application. We plan to enroll 60 new patients per year for the first two years, and 40 patients per year for each year thereafter, and maintain enrollees in long term follow-up (up to four years). Sixty percent of enrollees will be women and a major focus will be the long term evaluation of HIV expression and shedding in different compartments, particularly the genital tract. In addition, this site has a well established program for the integration of HIV care for incarcerated individuals into continuing post-release health care in the community. This experience will be brought to bear on the enrollment and follow- up of incarcerated individuals into controlled clinical trials. In particular, investigators on the grant, Doctors Timothy Flanigan, Susan Cu Uvin, Charles Carpenter, Ken Mayer, and Karen Tashima have an extensive background of long-term clinical studies focused on HIV and women. This expertise can be brought to a larger clinical trials network in order to expand and focus an agenda regarding HIV and women. This well integrated clinical site has an established record of working in close collaboration with investigators at Massachusetts General Hospital (MGH) in order to explore virologic expression and development of resistance in the genital tract and the CSF. This clinical site will be able to contribute to the agenda of long term viral suppression in all compartments utilizing combination therapies, particularly among women and hard to reach populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI046381-05
Application #
6699361
Study Section
Special Emphasis Panel (ZAI1-PSS-A (S1))
Program Officer
Germuga, Donna E
Project Start
2000-01-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2006-12-31
Support Year
5
Fiscal Year
2004
Total Cost
$1,367,405
Indirect Cost
Name
Miriam Hospital
Department
Type
DUNS #
063902704
City
Providence
State
RI
Country
United States
Zip Code
02906
Thio, Chloe L; Smeaton, Laura; Hollabaugh, Kimberly et al. (2015) Comparison of HBV-active HAART regimens in an HIV-HBV multinational cohort: outcomes through 144 weeks. AIDS 29:1173-82
Sacktor, Ned; Miyahara, Sachiko; Evans, Scott et al. (2014) Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol 20:620-6
Hulgan, Todd; Stein, James H; Cotter, Bruno R et al. (2013) Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. AIDS Res Hum Retroviruses 29:1293-9
Thio, Chloe L; Smeaton, Laura; Saulynas, Melissa et al. (2013) Characterization of HIV-HBV coinfection in a multinational HIV-infected cohort. AIDS 27:191-201
Wohl, David A; Kendall, Michelle A; Feinberg, Judith et al. (2013) The clinical impact of continuing to prescribe antiretroviral therapy in patients with advanced AIDS who manifest no virologic or immunologic benefit. PLoS One 8:e78676
Huang, Jeannie S; Hughes, Michael D; Riddler, Sharon A et al. (2013) Bone mineral density effects of randomized regimen and nucleoside reverse transcriptase inhibitor selection from ACTG A5142. HIV Clin Trials 14:224-34
Kang, M; Cu-Uvin, S (2012) Association of HIV viral load and CD4 cell count with human papillomavirus detection and clearance in HIV-infected women initiating highly active antiretroviral therapy. HIV Med 13:372-8
Sacktor, N; Miyahara, S; Deng, L et al. (2011) Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology 77:1135-42
Ribaudo, Heather J; Benson, Constance A; Zheng, Yu et al. (2011) No risk of myocardial infarction associated with initial antiretroviral treatment containing abacavir: short and long-term results from ACTG A5001/ALLRT. Clin Infect Dis 52:929-40
Haubrich, Richard H; Riddler, Sharon A; Ribaudo, Heather et al. (2011) Initial viral decay to assess the relative antiretroviral potency of protease inhibitor-sparing, nonnucleoside reverse transcriptase inhibitor-sparing, and nucleoside reverse transcriptase inhibitor-sparing regimens for first-line therapy of HIV infection AIDS 25:2269-78

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