This application or an HIV Prevention Trial Unit (HPTU) describes the relevant experience, the exceptional research infrastructure, the access to high risk drug using populations, and the scientific depth of HIV prevention research at the University of Pennsylvania site. The work proposed here is responsive to the RFA and it is sharply focused on those segments of the population at highest risk of HIV infection. Although our site will initially focus exclusively on domestic populations, we believe the findings of these studies will also inform prevention sciences internationally and support expanded prevention trials in other countries. Building upon our successful involvement as a HIVNET site and with the addition of several key investigators, this application proposes work in three of the PTN scientific areas: l) microbicides; 2) behavioral interventions, and 3) substance related transmission. Specifically we propose to: * Conduct three Phase I microbicide studies with 30 subjects each * Participate in a Phase IIb study of a women's behavioral intervention with 500 high risk drug using women * Conduct a Phase I study of the behavior change among high risk IDUs The research agenda described in this application represents an extension of our current research activities. Proposed investigators are currently implementing several HIVNET funded protocols including a Phase II vaccine trial, a Phase I microbicide trial, and a feasibility study of a behavioral intervention for women. Additionally, these investigators are conducting HIV prevention research with support from NIDA, NIMH, and the CDC. These activities include a longitudinal study of injection drug users investigating the role of syringe exchange as a bridge to substance abuse treatment (NIDA); a study of the behavioral impact of a community based intervention targeting African American mothers and their adolescent sons (NIMH); and a Phase IV study of a school-based behavioral intervention involving 11,000 adolescents (CDC). This application will also bring together investigators able to contribute to the future scientific agenda of the PTN. Penn PTU investigators have extensive expertise in the areas of substance abuse treatment, women's behavioral interventions, behavioral interventions with adolescents, microbicide research, health policy, and evaluation design. Thus, an additional aim of our group is to be active participants in three of the PTN science working groups-Microbicides, Behavioral Intervention, and Substance Related Transmission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01AI048014-05S2
Application #
7285136
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Black, Roberta J
Project Start
2000-07-01
Project End
2007-12-31
Budget Start
2006-09-15
Budget End
2007-12-31
Support Year
5
Fiscal Year
2006
Total Cost
$1,884,755
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Simmons, Nicole; Donnell, Deborah; Ou, San-San et al. (2015) Assessment of contamination and misclassification biases in a randomized controlled trial of a social network peer education intervention to reduce HIV risk behaviors among drug users and risk partners in Philadelphia, PA and Chiang Mai, Thailand. AIDS Behav 19:1818-27
Latkin, Carl; Donnell, Deborah; Liu, Ting-Yuan et al. (2013) The dynamic relationship between social norms and behaviors: the results of an HIV prevention network intervention for injection drug users. Addiction 108:934-43
Williams, Chyvette; Eisenberg, Marlene; Becher, Julie et al. (2013) Racial disparities in HIV prevalence and risk behaviors among injection drug users and members of their risk networks. J Acquir Immune Defic Syndr 63 Suppl 1:S90-4
Voytek, Chelsea D; Jones, Kevin T; Metzger, David S (2011) Selectively willing and conditionally able: HIV vaccine trial participation among women at ""high risk"" of HIV infection. Vaccine 29:6130-5
Hoffman, Susie; Morrow, Kate M; Mantell, Joanne E et al. (2010) Covert use, vaginal lubrication, and sexual pleasure: a qualitative study of urban U.S. Women in a vaginal microbicide clinical trial. Arch Sex Behav 39:748-60
Williams, Chyvette T; Metzger, David S (2010) Race and distance effects on regular syringe exchange program use and injection risks: a geobehavioral analysis. Am J Public Health 100:1068-74
Metzger, David S; Woody, George E; O'Brien, Charles P (2010) Drug treatment as HIV prevention: a research update. J Acquir Immune Defic Syndr 55 Suppl 1:S32-6
Metzger, David S; Zhang, Yan (2010) Drug treatment as HIV prevention: expanding treatment options. Curr HIV/AIDS Rep 7:220-5
Latkin, Carl A; Donnell, Deborah; Metzger, David et al. (2009) The efficacy of a network intervention to reduce HIV risk behaviors among drug users and risk partners in Chiang Mai, Thailand and Philadelphia, USA. Soc Sci Med 68:740-8
Latkin, Carl; Donnell, Deborah; Celentano, David D et al. (2009) Relationships between social norms, social network characteristics, and HIV risk behaviors in Thailand and the United States. Health Psychol 28:323-9

Showing the most recent 10 out of 20 publications