Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI056580-03
Application #
6838737
Study Section
Special Emphasis Panel (ZAI1-ALR-M (M4))
Program Officer
Zou, Lanling
Project Start
2003-08-15
Project End
2008-01-31
Budget Start
2005-02-01
Budget End
2006-01-31
Support Year
3
Fiscal Year
2005
Total Cost
$639,749
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Oscherwitz, Jon; Quinn, Conrad P; Cease, Kemp B (2015) Anthrax vaccine recipients lack antibody against the loop neutralizing determinant: A protective neutralizing epitope from Bacillus anthracis protective antigen. Vaccine 33:2342-6
Oscherwitz, Jon; Feldman, Daniel; Yu, Fen et al. (2015) Epitope-focused peptide immunogens in human use adjuvants protect rabbits from experimental inhalation anthrax. Vaccine 33:430-6
Oscherwitz, Jon; Yu, Fen; Jacobs, Jana L et al. (2013) Recombinant vaccine displaying the loop-neutralizing determinant from protective antigen completely protects rabbits from experimental inhalation anthrax. Clin Vaccine Immunol 20:341-9
Oscherwitz, Jon; Yu, Fen; Cease, Kemp B (2010) A synthetic peptide vaccine directed against the 2ß2-2ß3 loop of domain 2 of protective antigen protects rabbits from inhalation anthrax. J Immunol 185:3661-8
Oscherwitz, Jon; Yu, Fen; Cease, Kemp B (2009) A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen. Infect Immun 77:5509-18
Oscherwitz, Jon; Yu, Fen; Jacobs, Jana L et al. (2009) Synthetic peptide vaccine targeting a cryptic neutralizing epitope in domain 2 of Bacillus anthracis protective antigen. Infect Immun 77:3380-8
Oscherwitz, Jon; Hankenson, F C; Yu, Fen et al. (2006) Low-dose intraperitoneal Freund's adjuvant: toxicity and immunogenicity in mice using an immunogen targeting amyloid-beta peptide. Vaccine 24:3018-25