Abstract

This application proposes to establish an International Epidemiologic Database to Evaluate AIDS (IEDEA) Regional Center to harmonize HIV data and data collection in Region 9 - Central Africa. A Regional Data Center, backstopped by Research Triangle International (RTI), Research Triangle Park, North Carolina will be located in Kinshasa, Democratic Republic of Congo (DRC) at the University of North Carolina/DRC UNC/DRC) HIV/AIDS Clinical Research Unit at the Kinshasa School of Public Health. This multi-step research and capacity building process will occur through regional expansion/reinforcement of the existing partnership between the UNC's School of Public Health, the Kinshasa School of Public Health, RTI and the DR Congo's Programme National Multisectoriel de Lutte centre le SIDA (PNMLS). Additional international collaborators are: (1) Institute of Tropical Medicine in Antwerp, Belgium;(2) Institut National d'Etudes Demographiques Research Unites Mortalite Sante Epidemiologie et Population and Developpement, Paris, France;(3) Institut de Recherche pour le Developpement and Department of International Health, University of Montpellier, Montpellier France. Region 9 collaborators from Burundi, Cameroon, Central African Republic, Congo/Brazzaville, Democratic Republic of Congo, and Rwanda include HIV/AIDS clinicians /care providers, representatives of national HIV programs, and faculty from national medical schools. Our regional consortium has 20,200 patients currently on ARV's in a database and are following an additional 46,000 HIV-infected individuals who are not yet eligible to receive ART treatment. Harmonization of data across our region is the initial goal. When this is in place, our proposed research agenda will include: (1) Identify new region-appropriate models of HIV care and systems for monitoring its efficacy;(2) Monitor sentinel populations for ARV resistance;(3) Determine the role the high rate of genetic diversity for HIV seen in this region plays on ARV resistance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI069927-04
Application #
7651222
Study Section
Special Emphasis Panel (ZAI1-JB-A (J3))
Program Officer
Zimand, Lori B
Project Start
2006-07-01
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
4
Fiscal Year
2009
Total Cost
$1,480,130
Indirect Cost

  Institution

Name
Research Triangle Institute
Department
Type
DUNS #
004868105
City
Research Triangle
State
NC
Country
United States
Zip Code
27709

  Publications

Wools-Kaloustian, Kara; Marete, Irene; Ayaya, Samuel et al. (2018) Time to First-Line ART Failure and Time to Second-Line ART Switch in the IeDEA Pediatric Cohort. J Acquir Immune Defic Syndr 78:221-230
Napierala Mavedzenge, Sue; Newman, Jamie E; Nduwimana, Martin et al. (2017) HIV infection among children and adolescents in Burundi, Cameroon, and the Democratic Republic of Congo. AIDS Care 29:1026-1033
Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Breger, Tiffany L; Newman, Jamie E; Mfangam Molu, Brigitte et al. (2017) Self-disclosure of HIV status, disclosure counseling, and retention in HIV care in Cameroon. AIDS Care 29:838-845
Brown, Steven A; Abbas, Salma; Davies, Mary-Ann et al. (2017) Brief Report: Pediatric Cancer Burden and Treatment Resources Within the Pediatric IeDEA Consortium. J Acquir Immune Defic Syndr 76:60-64
Stolka, Kristen; Iriondo-Perez, Jeniffer; Kiumbu, Modeste et al. (2016) Characteristics of antiretroviral therapy-naïve patients lost-to-care in HIV clinics in Democratic Republic of Congo, Cameroon, and Burundi. AIDS Care 28:913-8
Yotebieng, Marcel; Meyers, Tammy; Behets, Frieda et al. (2015) Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries. AIDS 29:101-9
Koller, Manuel; Patel, Kunjal; Chi, Benjamin H et al. (2015) Authors' Reply: Early Initiation of Antiretroviral Therapy Among Young Children: A Long Way to Go. J Acquir Immune Defic Syndr 70:e71-2
Koller, Manuel; Patel, Kunjal; Chi, Benjamin H et al. (2015) Immunodeficiency in children starting antiretroviral therapy in low-, middle-, and high-income countries. J Acquir Immune Defic Syndr 68:62-72
Freeman, Anna; Kiumbu, Modeste; Mwamba, Blaise et al. (2014) Patient outcomes in Lubumbashi, Democratic Republic of Congo after a disruption in HIV care due to decreased global fund appropriations. AIDS Behav 18:2135-43

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