This application proposes to establish The University of North Carolina at Chapel Hill as a new site for the Women's Interagency HIV Study (WIHS). The proposal represents a collaborative effort between investigators from The UNC Center for Infectious Diseases, Center for AIDS Research, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research. We propose to rapidly establish the UNC-WIHS cohort, contribute meaningfully to the national WIHS scientific program, and undertake an ambitious HIV research agenda that encompasses social epidemiology and health outcomes, advanced epidemiologic and biostatistical methods, pathogenesis, and molecular biology of cancer.
We aim to: 1) Recruit and retain in follow-up a cohort of 200 HIV+ and 100 HIV- women who are at high risk for HIV infection and represent NC's HIV epidemic, thus expanding the WIHS Cohort to women who live in a region at the forefront of the US epidemic; 2) Characterize the relationship between socioeconomic context, changes in access to health insurance, and health outcomes among HIV+ and HIV- women; 3) Develop and apply novel epidemiologic and statistical methods using data from the UNC-WIHS and the entire WIHS cohort; 4) Characterize HIV persistence in the blood and genital tract among pre- and post-menopausal women; and 5) Investigate the pathobiology of breast and cervical cancers to identify immunological, microbial and genetic factors that affect cancer progression and treatment in HIV positive women. By contributing a diverse and complementary population of women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the WIHS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of HIV+ women and women at high risk for HIV infection.

Public Health Relevance

This application proposes to establish The University of North Carolina (UNC) at Chapel Hill as a new site for the Women's Interagency HIV Study (WIHS). We propose to rapidly establish the UNC-WIHS cohort, contribute meaningfully to the national WIHS scientific program, and undertake an ambitious HIV research agenda that encompasses social epidemiology and health outcomes, advanced epidemiologic and biostatistical methods, pathogenesis, and molecular biology of cancer. By contributing a diverse and complementary population of women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the WIHS, expand the range of questions that can be addressed, and improve the health of HIV+ women and women at high risk for HIV infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
4U01AI103390-04
Application #
8990810
Study Section
Special Emphasis Panel (ZAI1-RB-A (S1))
Program Officer
Roe, Joanad'Arc C
Project Start
2013-01-10
Project End
2017-12-31
Budget Start
2016-01-01
Budget End
2016-12-31
Support Year
4
Fiscal Year
2016
Total Cost
$1,763,483
Indirect Cost
$401,797
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Lesko, Catherine R; Buchanan, Ashley L; Westreich, Daniel et al. (2018) The Authors Respond. Epidemiology 29:e14-e15
Lesko, Catherine R; Edwards, Jessie K; Cole, Stephen R et al. (2018) When to Censor? Am J Epidemiol 187:623-632
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Ghosh, Mimi; Daniels, Jason; Pyra, Maria et al. (2018) Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. PLoS One 13:e0198412
Rice, Whitney S; Logie, Carmen H; Napoles, Tessa M et al. (2018) Perceptions of intersectional stigma among diverse women living with HIV in the United States. Soc Sci Med 208:9-17
Adams, Leah M; Wilson, Tracey E; Merenstein, Daniel et al. (2018) Using the Center for Epidemiologic Studies Depression Scale to assess depression in women with HIV and women at risk for HIV: Are somatic items invariant? Psychol Assess 30:97-105
Haley, Danielle F; Edmonds, Andrew; Schoenbach, Victor J et al. (2018) Associations between county-level voter turnout, county-level felony voter disenfranchisement, and sexually transmitted infections among women in the Southern United States. Ann Epidemiol :
Galárraga, Omar; Rana, Aadia; Rahman, Momotazur et al. (2018) The effect of unstable housing on HIV treatment biomarkers: An instrumental variables approach. Soc Sci Med 214:70-82
Enkhmaa, Byambaa; Anuurad, Erdembileg; Zhang, Wei et al. (2018) Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study. J Lipid Res 59:1967-1976
Rubin, Leah H; Benning, Lorie; Keating, Sheila M et al. (2018) Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study. J Neurovirol 24:41-51

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