The major goals in treating musculoskeletal system disorders are to decrease pain and improve function. There are many existing patient-reported outcome (PRO) instruments that measure pain and function related to various musculoskeletal conditions. Yet meaningful interpretation of these instruments is often lacking. To our knowledge, there are no published reports regarding the responsiveness and minimal clinically importance difference of the Patient-Reported Outcomes Information System (PROMIS) instruments for the orthopaedic patient population. Furthermore, measurements from different PRO instruments cannot be directly compared. Our overall goal is to provide a clear clinical interpretation of the PRO instruments used in musculoskeletal care and research. This 3-year, integrated and collaborative project has three steps: (1) Establish relationships between the legacy scale scores and the PROMIS Physical Function and Pain Interference scores to enable comparisons of results across studies; (2) Evaluate responsiveness to change of the legacy and the PROMIS instruments; and (3) Establish the minimum clinically important difference for the legacy and the PROMIS instruments for meaningful score interpretation. Our investigative team has expertise in clinical care of musculoskeletal diseases, clinical trials, quality of life assessment, instrument development, bioinformatics, and complex statistical analysis. This, in concert with exceptional resources for data collection, a high volume clinical patient source and a strong collaborative research environment, will provide an ideal environment for the proposed project.

Public Health Relevance

Musculoskeletal diseases have an enormous impact on health, affecting half of those 65 years and older. Our goal is to establish benchmarks and interpretability in patient-reported outcome measures. These can then be used to evaluate clinical treatment alternatives and help clinicians inform patients of outcomes after treatment.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZAR1-XZ (M2))
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Washabaugh, Charles H
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University of Utah
Schools of Medicine
Salt Lake City
United States
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Anderson, Michael R; Houck, Jeff R; Saltzman, Charles L et al. (2018) Validation and Generalizability of Preoperative PROMIS Scores to Predict Postoperative Success in Foot and Ankle Patients. Foot Ankle Int 39:763-770
Hung, Man; Voss, Maren W; Bounsanga, Jerry et al. (2018) Psychometrics of the Patient-Reported Outcomes Measurement Information System Physical Function instrument administered by computerized adaptive testing and the Disabilities of Arm, Shoulder and Hand in the orthopedic elbow patient population. J Shoulder Elbow Surg 27:515-522
Brodke, Darrel S; Goz, Vadim; Voss, Maren W et al. (2017) PROMIS PF CAT Outperforms the ODI and SF-36 Physical Function Domain in Spine Patients. Spine (Phila Pa 1976) 42:921-929
Kazmers, Nikolas H; Hung, Man; Rane, Ajinkya A et al. (2017) Association of Physical Function, Anxiety, and Pain Interference in Nonshoulder Upper Extremity Patients Using the PROMIS Platform. J Hand Surg Am 42:781-787
Hung, Man; Voss, Maren W; Bounsanga, Jerry et al. (2017) Examination of the PROMIS upper extremity item bank. J Hand Ther 30:485-490
Hung, Man; Bounsanga, Jerry; Tang, Philip et al. (2015) The factor structure of the hospital anxiety and depression scale in orthopedic trauma patients. J Clin Med Res 7:453-9
Beckmann, James T; Hung, Man; Bounsanga, Jerry et al. (2015) Psychometric evaluation of the PROMIS Physical Function Computerized Adaptive Test in comparison to the American Shoulder and Elbow Surgeons score and Simple Shoulder Test in patients with rotator cuff disease. J Shoulder Elbow Surg 24:1961-7
Hung, Man; Hon, Shirley D; Cheng, Christine et al. (2014) Psychometric Evaluation of the Lower Extremity Computerized Adaptive Test, the Modified Harris Hip Score, and the Hip Outcome Score. Orthop J Sports Med 2:2325967114562191