Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
7U01CA051992-03
Application #
3549535
Study Section
Special Emphasis Panel (SRC (42))
Project Start
1990-06-15
Project End
1995-05-31
Budget Start
1992-09-30
Budget End
1993-05-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Onyx Pharmaceuticals
Department
Type
DUNS #
City
Richmond
State
CA
Country
United States
Zip Code
94080
Hu, J S; Redfield, A G (1997) Conformational and dynamic differences between N-ras P21 bound to GTPgammaS and to GMPPNP as studied by NMR. Biochemistry 36:5045-52
Bellew, B F; Halkides, C J; Gerfen, G J et al. (1996) High frequency (139.5 GHz) electron paramagnetic resonance characterization of Mn(II)-H2(17)O interactions in GDP and GTP forms of p21 ras. Biochemistry 35:12186-93
Scheidig, A J; Franken, S M; Corrie, J E et al. (1995) X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J Mol Biol 253:132-50
Ruggieri, R; Macdonald, S G; Callow, M et al. (1994) Raf-1 interferes with Ras and Rap1A effector functions in yeast. Mol Biol Cell 5:173-81
Halkides, C J; Farrar, C T; Larsen, R G et al. (1994) Characterization of the active site of p21 ras by electron spin-echo envelope modulation spectroscopy with selective labeling: comparisons between GDP and GTP forms. Biochemistry 33:4019-35
Cook, S J; McCormick, F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262:1069-72
Hu, J S; Redfield, A G (1993) Mapping the nucleotide-dependent conformational change of human N-ras p21 in solution by heteronuclear-edited proton-observed NMR methods. Biochemistry 32:6763-72
Miller, A F; Halkides, C J; Redfield, A G (1993) An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras. Biochemistry 32:7367-76
Cook, S J; Rubinfeld, B; Albert, I et al. (1993) RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J 12:3475-85
Miller, A F; Papastavros, M Z; Redfield, A G (1992) NMR studies of the conformational change in human N-p21ras produced by replacement of bound GDP with the GTP analog GTP gamma S. Biochemistry 31:10208-16

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