Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA052857-03S1
Application #
3549600
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1990-06-15
Project End
1995-05-31
Budget Start
1992-09-01
Budget End
1993-05-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Tyler, Betty M; Hdeib, Alia; Caplan, Justin et al. (2012) Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel. J Neurosurg Spine 16:93-101
Tyler, Betty; Fowers, Kirk D; Li, Khan W et al. (2010) A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats. J Neurosurg 113:210-7
Slager, Joram; Tyler, Betty; Shikanov, Ariella et al. (2009) Local controlled delivery of anti-neoplastic RNAse to the brain. Pharm Res 26:1838-46
Brem, Sarah; Tyler, Betty; Li, Khan et al. (2007) Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model. Cancer Chemother Pharmacol 60:643-50
Sampath, Prakash; Rhines, Laurence D; DiMeco, Francesco et al. (2006) Interstitial docetaxel (taxotere), carmustine and combined interstitial therapy: a novel treatment for experimental malignant glioma. J Neurooncol 80:9-17
Hsu, Wesley; Lesniak, Maciej S; Tyler, Betty et al. (2005) Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma. J Neurooncol 74:135-40
Lesniak, Maciej S; Upadhyay, Urvashi; Goodwin, Rory et al. (2005) Local delivery of doxorubicin for the treatment of malignant brain tumors in rats. Anticancer Res 25:3825-31
Lesniak, Maciej S; Gabikian, Patrick; Tyler, Betty M et al. (2004) Dexamethasone mediated inhibition of local IL-2 immunotherapy is dose dependent in experimental brain tumors. J Neurooncol 70:23-8
Sampath, Prakash; Amundson, Eric; Wall, Monroe E et al. (2003) Camptothecin analogs in malignant gliomas: comparative analysis and characterization. J Neurosurg 98:570-7
Lesniak, Maciej S; Tyler, Betty M; Pardoll, Drew M et al. (2003) Gene therapy for experimental brain tumors using a xenogenic cell line engineered to secrete hIL-2. J Neurooncol 64:155-60

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