Abstract

This study combines techniques in genetic epidemiology and molecular genetics to define and characterize inherited breast and breast/ovarian cancer predisposing syndromes. It focuses on two hereditary syndromes: (1) the Li-Fraumeni syndrome, known to be caused by mutations in the tumor suppressor gene p53 at l7p13.1; and (2) a newly defined breast/ovary syndrome which is linked to genetic markers at 17q2l. The California state-mandated Cancer Surveillance Program of Orange County (CSPOC) will be used to identify 500 early onset (

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA058860-04
Application #
2429771
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1994-02-04
Project End
1998-09-29
Budget Start
1997-01-01
Budget End
1998-09-29
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Carpenter, Philip M; Ziogas, Argyrios; Markham, Emma M et al. (2018) Laminin 332 expression and prognosis in breast cancer. Hum Pathol 82:289-296
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Milne, Roger L (see original citation for additional authors) (2017) Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nat Genet 49:1767-1778
Muranen, Taru A; Greco, Dario; Blomqvist, Carl et al. (2017) Genetic modifiers of CHEK2*1100delC-associated breast cancer risk. Genet Med 19:599-603
Hampras, Shalaka S; Sucheston-Campbell, Lara E; Cannioto, Rikki et al. (2016) Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer. Oncotarget 7:69097-69110
Wyszynski, Asaf; Hong, Chi-Chen; Lam, Kristin et al. (2016) An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum Mol Genet 25:3863-3876
Schmidt, Marjanka K; Hogervorst, Frans; van Hien, Richard et al. (2016) Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. J Clin Oncol 34:2750-60
Zeng, Chenjie (see original citation for additional authors) (2016) Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res 18:64
Mavaddat, Nasim; Pharoah, Paul D P; Michailidou, Kyriaki et al. (2015) Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst 107:
Chornokur, Ganna; Lin, Hui-Yi; Tyrer, Jonathan P et al. (2015) Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk. PLoS One 10:e0128106

Showing the most recent 10 out of 66 publications