This application responds to the need for an Operations and Statistical Center to support a 3D Radiation Dose Escalation Study for Prostate Cancer (RFA 92-CA-05). The proposed centers will be based at the American College of Radiology and the Mallinckrodt Institute of Radiology. This application requests support to: 1) establish a cooperative working group to develop Phase I-II 3D-CRT studies for carcinoma of the prostate; 2) develop criteria for participation that assure 3D-CRT and allow subsequent quality assurance reviews; 3) further develop digital data exchange mechanisms as a basis for monitoring protocol compliance; 4) develop and maintain a 3D data base as a means of analyzing toxicity as a function of dose and volume; and 5) develop Phase III trials comparing high dose 3D-CRT trials versus standard dose radiation therapy. The Operations and Statistical Centers will actively participate in the preparation of abstracts and manuscripts prepared based on the findings of this cooperative research efforts.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01CA060267-01
Application #
3550108
Study Section
Special Emphasis Panel (SRC (62))
Project Start
1993-06-01
Project End
1997-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost
Name
American College of Radiology
Department
Type
DUNS #
City
Philadelphia
State
VA
Country
United States
Zip Code
Valicenti, Richard K; Winter, Kathryn; Cox, James D et al. (2003) RTOG 94-06: is the addition of neoadjuvant hormonal therapy to dose-escalated 3D conformal radiation therapy for prostate cancer associated with treatment toxicity? Int J Radiat Oncol Biol Phys 57:614-20
Michalski, Jeff M; Winter, Kathryn; Purdy, James A et al. (2002) Trade-off to low-grade toxicity with conformal radiation therapy for prostate cancer on Radiation Therapy Oncology Group 9406. Semin Radiat Oncol 12:75-80
Michalski, J M; Purdy, J A; Winter, K et al. (2000) Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG/RTOG 9406. Int J Radiat Oncol Biol Phys 46:391-402
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