Abstract

The goal of the project is to investigate the relationship between angiogenesis in stage II, III or IV breast cancer and clinical outcome. Parameters to be measured include circulating and urinary basic fibroblast growth factor (bFGF), degree of neovascularization and tissue TGF- B1 expression. Specimens to be analyzed have been or will be collected from women participating in prospective therapeutic trials of CALGB. Analysis will allow a correlation of angiogenesis and putative markers (circulating or urinary bFGF and tissue TGF-B1) with treatment outcome.Such knowledge could lead to clinically useful predictors of prognosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA064057-05
Application #
2606515
Study Section
Special Emphasis Panel (SRC (80))
Program Officer
Xie, Heng
Project Start
1994-06-01
Project End
1999-03-31
Budget Start
1997-02-01
Budget End
1999-03-31
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057