) MRI of the breast provides higher soft tissue contrast than conventional breast imaging (mammography). This provides the potential for improved lesion detection and characterization. Studies have already demonstrated the potential for breast MRI to distinguish benign from malignant breast lesions and to detect mammographically and clinically occult cancer. In response to RFA CA-96-012, a consortium of 14 clinical sites has been organized to perform a study on the performance characteristics of breast MRI in : detecting and diagnosing lesions in patients with suspicious mammographic or clinical findings and determining the extent of cancer within an affected breast. In addition to characterizing the performance of breast MRI as described above, factors affecting the performance such as prior knowledge of historical and mammographic features will also be evaluated. In particular, the relative importance of high resolution and dynamic imaging will be assessed. In addition, this consortium will conduct a pilot study to investigate the feasibility of screening patients that carry a breast cancer susceptibility gene with MRI. The 14 clinical sites provide experts in breast imaging, clinical MRI and MR physics to serve on the Executive and Quality Assurance committees. In addition to the clinical sites, the consortium contains mammography, and pathology Quality Assurance facilities to support this trial. The consortium has formed strategic partnerships with industry in order to acquire technical expertise in the MRI equipment used in this study and to acquire the contrast agents to be used in the study. The expertise represented in the consortium and its industry partners makes it uniquely qualified to carry out this research program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA074680-05
Application #
6376436
Study Section
Special Emphasis Panel (ZCA1-RLB-Y (J2))
Project Start
1997-09-30
Project End
2004-01-31
Budget Start
2001-08-08
Budget End
2004-01-31
Support Year
5
Fiscal Year
2001
Total Cost
$780,749
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Lehman, Constance D; Isaacs, Claudine; Schnall, Mitchell D et al. (2007) Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study. Radiology 244:381-8
Schnall, Mitchell D; Blume, Jeffrey; Bluemke, David A et al. (2006) Diagnostic architectural and dynamic features at breast MR imaging: multicenter study. Radiology 238:42-53
Lehman, Constance D; Blume, Jeffrey D; Thickman, David et al. (2005) Added cancer yield of MRI in screening the contralateral breast of women recently diagnosed with breast cancer: results from the International Breast Magnetic Resonance Consortium (IBMC) trial. J Surg Oncol 92:9-15; discussion 15-6
Schnall, Mitchell D; Blume, Jeffery; Bluemke, David A et al. (2005) MRI detection of distinct incidental cancer in women with primary breast cancer studied in IBMC 6883. J Surg Oncol 92:32-8
Lehman, Constance D; Blume, Jeffrey D; Weatherall, Paul et al. (2005) Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer 103:1898-905
Bluemke, David A; Gatsonis, Constantine A; Chen, Mei Hsiu et al. (2004) Magnetic resonance imaging of the breast prior to biopsy. JAMA 292:2735-42