This application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California between 1993 and 1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the senior investigators in nutrition, ethnic/racial studies, and, subsequently, genetics. It is the most ethnically heterogeneous cancer cohort in existence. At baseline, the cohort included information on 215,000 men and women, comprised, by design, almost entirely of five ethnic/racial populations: Caucasians, Japanese Americans, Native Hawaiians, African Americans, and Latinos. The resource was later expanded to include a prospective bio repository of blood and urine specimens from ~ 70,000 of the participants. Leadership of the MEC entails a highly interactive, team approach; and the investigators have amply demonstrated their willingness to share data and participate actively in consortium projects. This application describes our aims over the next five years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research in the areas of genetic and nutritional epidemiology that utilize the resources of the cohort. Research accomplishments to date include significant contributions to understanding both genetic and environmental risk factors for cancer, particularly related to breast, prostate, colorectal and lun cancers. Nearly 250 papers describing these findings have been published. In addition, primarily over the last 20 years, more than 50 research grants have been built around the MEC, and more than 50 students and postdoctoral fellows have been trained on the study. This new grant will make possible the continuation of a well-integrated program of research aimed at evaluating environmental factors and genetic variants as risk factors for cancer and other common chronic diseases.
The Multiethnic Cohort Study is a powerful resource for continuing research efforts aimed at greater understanding ofthe environmental causes of cancer and other chronic diseases, and how these risk factors interact with genetic variants to explain some of the ethnic/racial disparities in cancer risks in the U,S. population. It is our hope that this work ultimately will provide useful insights into the prevention, early detection and treatment of cancer
| Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390 |
| O'Reilly, Éilis J; Bjornevik, Kjetil; Schwarzschild, Michael A et al. (2018) Pre-diagnostic plasma urate and the risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 19:194-200 |
| Park, Sungshim L; Cheng, Iona; Haiman, Christopher A (2018) Genome-Wide Association Studies of Cancer in Diverse Populations. Cancer Epidemiol Biomarkers Prev 27:405-417 |
| Lim, Unhee; Monroe, Kristine R; Buchthal, Steve et al. (2018) Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups. Gastroenterology : |
| Maskarinec, Gertraud; Ju, Dan; Fong, Jaimie et al. (2018) Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin. BMC Cancer 18:1191 |
| Amshoff, Yvette; Maskarinec, Gertraud; Shvetsov, Yurii B et al. (2018) Type 2 diabetes and colorectal cancer survival: The multiethnic cohort. Int J Cancer 143:263-268 |
| Van Dyke, Alison L; Langhamer, Margaret S; Zhu, Bin et al. (2018) Family History of Cancer and Risk of Biliary Tract Cancers: Results from the Biliary Tract Cancers Pooling Project. Cancer Epidemiol Biomarkers Prev 27:348-351 |
| Maskarinec, Gertraud; Jacobs, Simone; Amshoff, Yvette et al. (2018) Sleep duration and incidence of type 2 diabetes: the Multiethnic Cohort. Sleep Health 4:27-32 |
| Cologne, John; Loo, Lenora; Shvetsov, Yurii B et al. (2018) Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort. BMC Genomics 19:524 |
| Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430 |
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