The goal of this competing renewal application is to support the core infrastructure and continued follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort (CEC) established in 1986 and including 51,529 male health professionals age 40 to 75 years at baseline. This cohort is unique in its focus on men's health and follow-up of almost three decades, a time frame that is essential to realistically understand the relation between modifiable factors and cancer risk. Over this period of time, data has been regularly updated on diet, activity, smoking, weight, medications, and other potentially modifiable determinants of cancer risk. An extensive biorepository has been established that includes DNA from most participants, toenails, red cells, and plasma. Tumor tissue has been obtained from a high percentage of incident prostate and colorectal cancers; a recent supplement is supporting collection of tissue for less common tumors and noncancerous prostate tissue. Cohort follow-up has been consistently 90% or higher at each two-year cycle and mortality follow-up is virtually complete. Epidemiological studies from the HPFS, alone and through participation in consortia, have helped elucidate risk factors for cancer incidence and determinants of cancer survival in men. With cohort members now in an age of high cancer incidence, the HPFS is in a highly productive phase. During the current funding cycle, 325 papers have been published that utilize data and/or biological samples from HPFS; 200 of these have specifically examined cancer or cancer precursor outcomes. To date, 13,346 participants have been diagnosed with cancer and 3,571 cancer deaths have occurred; 5,791 men in HPFS are currently living with a cancer diagnosis. In the next funding cycle, we propose the following aims. 1-) To continue active follow-up for cancer incidence and mortality and to update exposure data pre and post-diagnosis of cancer. 2-) To update the food composition database that supports dietary assessment in HPFS and the Nurses' Health Study I and II cohorts. 3-) To leverage a recently completed validation study of physical activity and collaborate with colleagues in two multiethnic cohorts of men to calibrate physical activity questions. 4-) To make a first time linkage to Medicare Claims data. 5-) To maintain the HPFS cancer tissue biorepository, and expand collections of prostate and colon, and undertake a new collection of lung cancer in nonsmokers. 6-) To maintain the other biorepositories including plasma, red blood cells, germline DNA, and toenail samples. 7-) To undertake a new post-diagnostic blood collection among men with prostate cancer. 8-) To maintain and augment the statistical infrastructure and data management of the cohort. 9-) To facilitate resource sharing and collaborations with other CECs and outside investigators. With additional cohort follow- up, particularly after cancer diagnosis, the HPFS remains ideally positioned to make innovative contributions to our overall goal of reducing the burden of cancer by identifying primary and secondary prevention strategies.
This project will support the core infrastructure and follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort of 51,529 male health professionals followed for three decades since 1986. The cohort includes biennial questionnaires and prospectively collected biospecimens including: plasma, red cells, germline DNA, toenail samples, and tumor tissue. With additional follow-up of the cohort, particularly after cancer diagnosis, the cohort remains ideally positioned to make innovative contributions to the overall goal of reducing the burden of cancer and identifying primary and secondary prevention strategies.
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|Nguyen, Long H; Lochhead, Paul; Joshi, Amit D et al. (2018) No Significant Association Between Proton Pump Inhibitor Use and Risk of Stroke After Adjustment for Lifestyle Factors and Indication. Gastroenterology 154:1290-1297.e1|
|Joshu, Corinne E; Peskoe, Sarah B; Heaphy, Christopher M et al. (2018) Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells. Prostate 78:233-238|
|Kosumi, Keisuke; Hamada, Tsuyoshi; Koh, Hideo et al. (2018) The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol 188:2839-2852|
|Ferraro, Pietro Manuel; Taylor, Eric N; Gambaro, Giovanni et al. (2018) Vitamin B6 intake and the risk of incident kidney stones. Urolithiasis 46:265-270|
|Pernar, Claire H; Ebot, Ericka M; Pettersson, Andreas et al. (2018) A Prospective Study of the Association between Physical Activity and Risk of Prostate Cancer Defined by Clinical Features and TMPRSS2:ERG. Eur Urol :|
|Butt, Julia; Blot, William J; Teras, Lauren R et al. (2018) Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev 27:1186-1194|
|Liu, Gang; Li, Yanping; Hu, Yang et al. (2018) Influence of Lifestyle on Incident Cardiovascular Disease and Mortality in Patients With Diabetes Mellitus. J Am Coll Cardiol 71:2867-2876|
|Dadaev, Tokhir; Saunders, Edward J; Newcombe, Paul J et al. (2018) Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nat Commun 9:2256|
|Petrick, Jessica L; Campbell, Peter T; Koshiol, Jill et al. (2018) Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project. Br J Cancer 118:1005-1012|
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