This competing continuation application requests 3 years of funding to complete an ongoing multi-site study examining the efficacy of individual cognitive therapy (CT), individual supportive-expressive (SE) psychodynamic therapy, and individual drug counseling (IDC) when combined with group drug counseling compared with group drug counseling (GDC) alone for 480 patients who meet DSM-lV criteria for cocaine dependence. This project has been funded as a Cooperative Agreement involving two NIDA collaborators, a Coordinating Center at the U. of Pennsylvania, and treatment sites at Western Psychiatric Institute and Clinic (Pittsburgh), Brookside Hospital (Nashua, NH), McLean and Mass General Hospitals (Boston), and U. of Pennsylvania. During the last grant period we have recruited and trained our research teams, developed efficient screening procedures, standardized and established the reliability of our assessments, and trained therapists and counselors in state-of-the-art treatment methods that can be administered with a high degree of specificity and fidelity. These goals were accomplished in the course of conducting a pilot study involving 314 randomized patients that provided preliminary evidence for our hypotheses. The main trial began in July 1994 and thus far we have recruited 129 patients. We anticipate recruiting a total of 288 patients between July 1994 and the beginning of the competing continuation in September 1995 and an additional 192 patients in the first year of the renewal. Specifically, we hypothesize that CT, SE, and lDC will be better than GDC; that for patients with high levels of psychiatric severity CT and SE will be better than IDC, and that for patients with an external coping style CT will be better than SE. Treatment consists of a 6-month active phase followed by a 3 month booster phase. Assessments are done monthly through the active phase and at 9, 12, 15, and IS months post randomization to examine the long-term effects of treatment. The main outcome measures include urine results (dine weekly), Addiction Severity Index Drug Use composite, and self- report of cocaine use. A variety of secondary outcome measures are also obtained. The data analysis will use both cross-sectional and longitudinal approaches.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (SRCD (56))
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University of Pennsylvania
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United States
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Stulz, Niklaus; Thase, Michael E; Gallop, Robert et al. (2011) Psychosocial treatments for cocaine dependence: the role of depressive symptoms. Drug Alcohol Depend 114:41-8
Stulz, Niklaus; Gallop, Robert; Lutz, Wolfgang et al. (2010) Examining differential effects of psychosocial treatments for cocaine dependence: an application of latent trajectory analyses. Drug Alcohol Depend 106:164-72
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Crits-Christoph, Paul; Gibbons, Mary Beth Connolly; Barber, Jacques P et al. (2003) Mediators of outcome of psychosocial treatments for cocaine dependence. J Consult Clin Psychol 71:918-25
Woody, George E; Gallop, Robert; Luborsky, Lester et al. (2003) HIV risk reduction in the National Institute on Drug Abuse Cocaine Collaborative Treatment Study. J Acquir Immune Defic Syndr 33:82-7
Siqueland, Lynne; Crits-Christoph, Paul; Gallop, Bob et al. (2002) Who starts treatment: engagement in the NIDA collaborative cocaine treatment study. Am J Addict 11:10-23
Siqueland, Lynne; Crits-Christoph, Paul; Gallop, Robert et al. (2002) Retention in psychosocial treatment of cocaine dependence: predictors and impact on outcome. Am J Addict 11:24-40

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