In response to the RFA """"""""Diffusion of HIV Infection through Sexual Risk Behaviors of Drug Users"""""""", a team of established researchers from Yale University, the Hispanic Health Council, the Biomedical Center in St. Petersburg, Russia, and Imperial College, London have established a consortium. Together, they will participate as a single entity in the Sexual Acquisition and Transmission of HIV Cooperation Agreement Program (SATH-CAP). The multidisciplinary team will employ the methodologies of behavioral and molecular epidemiology, medical sociology and anthropology, and mathematical modeling to investigate the behaviors of injection drug users and their sex partners in two locations - Connecticut and St. Petersburg. These two sites have been chosen since they differ in terms of the stage of the HIV-1 epidemic among injectors. In Connecticut, the epidemic appears to be under control, with stable or declining prevalence; in St. Petersburg, the epidemic appears to be on the increase, with high incidence and rising prevalence. This application has four specific aims: 1) to establish a multidisciplinary team based on our competences and expertise to investigate the sexual and syringeborne transmission of HIV and other pathogens among populations of drug users and from drug users to the broader population; 2) to employ a multidisciplinary approach to investigate the dynamics of sexual and syringe-borne disease transmission in cohorts of injection drug users and their sexual partners in the two locations; 3) to trace sexual transmitted HIV-1 infections in St. Petersburg back to injectors to investigate the expansion of the epidemic from one concentrated in injectors to a more generalized one; and 4) to develop mathematical models and projections of disease spread in these populations that are informed by the quantitative, qualitative, and biological data.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DA017387-03
Application #
6930385
Study Section
Special Emphasis Panel (ZDA1-WXG-F (24))
Program Officer
Lambert, Elizabeth
Project Start
2003-09-30
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
3
Fiscal Year
2005
Total Cost
$970,720
Indirect Cost
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Dukhovlinova, Elena; Masharsky, Alexey; Toussova, Olga et al. (2015) Two Independent HIV Epidemics in Saint Petersburg, Russia Revealed by Molecular Epidemiology. AIDS Res Hum Retroviruses 31:608-14
Abdala, Nadia; Hansen, Nathan B; Toussova, Olga V et al. (2013) Correlates of unprotected sexual intercourse among women who inject drugs or who have sexual partners who inject drugs in St Petersburg, Russia. J Fam Plann Reprod Health Care 39:179-85
Mills, Harriet L; White, Edward; Colijn, Caroline et al. (2013) HIV transmission from drug injectors to partners who do not inject, and beyond: modelling the potential for a generalized heterosexual epidemic in St. Petersburg, Russia. Drug Alcohol Depend 133:242-7
Abdala, Nadia; Hansen, Nathan B; Toussova, Olga V et al. (2012) Age at first alcoholic drink as predictor of current HIV sexual risk behaviors among a sample of injection drug users (IDUs) and non-IDUs who are sexual partners of IDUs, in St. Petersburg, Russia. AIDS Behav 16:1597-604
Niccolai, Linda M; Verevochkin, Sergei V; Toussova, Olga V et al. (2011) Estimates of HIV incidence among drug users in St. Petersburg, Russia: continued growth of a rapidly expanding epidemic. Eur J Public Health 21:613-9
Ober, Allison J; Iguchi, Martin Y; Weiss, Robert E et al. (2011) The relative role of perceived partner risks in promoting condom use in a three-city sample of high-risk, low-income women. AIDS Behav 15:1347-58
Grau, Lauretta E; White, Edward; Niccolai, Linda M et al. (2011) HIV disclosure, condom use, and awareness of HIV infection among HIV-positive, heterosexual drug injectors in St. Petersburg, Russian Federation. AIDS Behav 15:45-57
Mackesy-Amiti, Mary Ellen; McKirnan, David J; Ouellet, Lawrence J (2010) Relationship characteristics associated with anal sex among female drug users. Sex Transm Dis 37:346-51
Paintsil, Elijah; He, Huijie; Peters, Christopher et al. (2010) Survival of hepatitis C virus in syringes: implication for transmission among injection drug users. J Infect Dis 202:984-90
Heimer, Robert; White, Edward (2010) Estimation of the number of injection drug users in St. Petersburg, Russia. Drug Alcohol Depend 109:79-83

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