The purpose of the Seek, Test, Treat, and Retain (STTR) Data Harmonization Coordinating Center (DCC) is to coordinate and support the use of an integrated harmonized data set to test the effectiveness of the STTR paradigm and to improve understanding of the intersection of HIV infection, drug abuse, and the HIV treatment cascade. This will require a DCC experienced in data harmonization, multi-site coordination, and research on drug abuse interventions and impact among persons living with HIV (PLWH) to comprehensively integrate clinical research data from multiple studies. Therefore, we propose the following aims: 1) Provide operational, administrative, and logistical support for the STTR data harmonization initiative 2) Identify and obtain access to STTR data from existing HIV sources. Inclusion of CNICS data has already been approved by the CNICS Executive Committee. 3) Work with a multi-disciplinary team of drug abuse and HIV experts, biostatisticians, epidemiologists, experts from NIDA, and other interested parties to develop and implement a state-of-the-art scientific agenda, including a dissemination and publication plan, that advances the understanding of drug abuse among PLWH, and facilitates studies of drug abuse and testing, engagement, treatment, and retention in care. We are ideally suited to lead the STTR DCC, bringing a background of clinical HIV research including substance use, expertise in biostatistics, epidemiology and project coordination, and vast experience with data harmonization for cohorts and studies of PLWH. We will test and advance emerging methods for integrating, analyzing, and interpreting harmonized large data sets;serve as a centralized resource to facilitate and support research site activities;and conduct cross-site analyses using the STTR integrated dataset. In consultation with NIDA and the study PIs, we will lead a strong research agenda focused on the clinical questions that requires the power of a consortium of studies to successfully elicit answers to generate new knowledge on the intersection of HIV, drug abuse and the HIV treatment cascade to inform future research and clinical care in the US and globally.

Public Health Relevance

The Seek, Test, Treat, Retain (STTR) strategy is based on growing evidence that HIV testing followed by immediate antiretroviral therapy for persons living with HIV (PLWH) could reduce HIV transmission to others. The STTR Data Harmonization Coordinating Center will bring together an interdisciplinary team of investigators experienced in data harmonization, multi-site coordination, and research on drug abuse interventions and impact among PLWH to coordinate and support the development and use of a large integrated dataset to test the effectiveness of the STTR strategy. This large data resource of comprehensively integrated clinical data from multiple studies will give researchers the potential to address important scientific and public health questions related to HIV prevention, drug abuse, and outcomes among PLWH that would not be possible with smaller studies.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-EXL-T (13))
Program Officer
Kahana, Shoshana Y
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Biostatistics & Other Math Sci
Schools of Public Health
United States
Zip Code
Beckwith, Curt G; Kuo, Irene; Fredericksen, Rob J et al. (2018) Risk behaviors and HIV care continuum outcomes among criminal justice-involved HIV-infected transgender women and cisgender men: Data from the Seek, Test, Treat, and Retain Harmonization Initiative. PLoS One 13:e0197730
McCollister, Kathryn E; Yang, Xuan; Murphy, Sean M et al. (2018) Criminal justice measures for economic data harmonization in substance use disorder research. Health Justice 6:17
Matsuzaki, Mika; Vu, Quan M; Gwadz, Marya et al. (2018) Perceived access and barriers to care among illicit drug users and hazardous drinkers: findings from the Seek, Test, Treat, and Retain data harmonization initiative (STTR). BMC Public Health 18:366
Delaney, Joseph A; Nance, Robin M; Whitney, Bridget M et al. (2018) Brief Report: Reduced Use of Illicit Substances, Even Without Abstinence, Is Associated With Improved Depressive Symptoms Among People Living With HIV. J Acquir Immune Defic Syndr 79:283-287
Chandler, Redonna; Gordon, Michael S; Kruszka, Bridget et al. (2017) Cohort profile: seek, test, treat and retain United States criminal justice cohort. Subst Abuse Treat Prev Policy 12:24
Loeliger, Kelsey B; Biggs, Mary L; Young, Rebekah et al. (2017) Gender Differences in HIV Risk Behaviors Among Persons Involved in the U.S. Criminal Justice System and Living with HIV or at Risk for HIV: A ""Seek, Test, Treat, and Retain"" Harmonization Consortium. AIDS Behav 21:2945-2957
Nance, Robin M; Delaney, J A Chris; Golin, Carol E et al. (2017) Co-calibration of two self-reported measures of adherence to antiretroviral therapy. AIDS Care 29:464-468