Bilingualism is an exponentially increasing trend in today's world population due to mass immigration and globalization. Nonetheless, there are no guidelines for the optimal rehabilitation for bilingual patients with aphasia, and this poses a great challenge to reducing health disparities. One of NIDCD's Health Disparities 2009-2013 Strategic Research Plan includes a goal to better treat aphasia in bilingual individuals ( The current research on this topic, however, lacks specific recommendations on which languages should be trained in a bilingual aphasic individual and to what extent cross-language transfer occurs subsequent to rehabilitation. Factors contributing to the paucity of research in this area relate to the multitude of possible language combinations in a bilingual individual, the relative competency of the two languages of the bilingual individual and the effect of focal brain damage on bilingual language representation. It is, however, unfeasible to examine these issues without undertaking a large scale longitudinal study in this population. As a potential solution, in our previous work, we developed a computational model to simulate language recovery following rehabilitation in bilingual aphasia. Specifically, we trained, lesioned, and retrained a bilingual computational model in order to systematically characterize the effect of AoA, pre-stroke language proficiency, and post-stroke naming output on the rehabilitation outcomes. Results demonstrated that a computational model including these variables was able to capture the many complex profiles that surface in aphasia both before and after intervention. In addition, it was able to predict the extent of cross-language generalization. However, the work of using this model to fully understand bilingual aphasia rehabilitation has just begun. In the proposed project, we extend this work to now examine the predictive abilities of the model and identify the factors that can maximize cross-language generalization. We also extend the architecture and functionality of this model, which was originally developed to simulate Spanish-English bilingual language processing, to Chinese-English which is another language combination commonly encountered in the US and has a strong theoretical and experimental foundation in computational modeling. The proposed work is innovative, because it uses a computational model to predict optimal rehabilitation protocols to facilitate the greatest amount of language recovery in bilingual aphasia. The successful completion of this project is expected to have an important impact on rehabilitation of stroke and bilingual aphasia as well as on the applications of computational modeling.

Public Health Relevance

This project is important because it will address the important issue of language recovery following treatment in individuals with bilingual aphasia by using a computational model to predict treatment outcomes in patients. It is predicted that the patients who are treated based on the model's predictions will outperform patients who are trained in the language opposite to the model's predictions, because each treatment plan is customized to that patient's impairment and bilingual language profile. This project will also provide a computational explanation for the hypothesis that different patterns of cross-language generalization in bilingual patients arise from facilitation and inhibition mechanisms on the computational maps. Finally, we will expand the architecture and functionality of the model from Spanish-English to Chinese-English to account for a different language structure. One of NIDCD's Health Disparities 2009-2013 Strategic Research Plan includes a goal to better treat aphasia in bilingual individuals. The proposed work will integrate two complementary scientific approaches (patient-oriented rehabilitation research and computational modeling) to achieve this goal.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project--Cooperative Agreements (U01)
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Language and Communication Study Section (LCOM)
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Cooper, Judith
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Boston University
Other Health Professions
Schools of Allied Health Profes
United States
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