In response to RFA DE-05-006, we have formed the """"""""Dental PBRN"""""""", a practice-based research network (PBRN) that includes six U.S. states and Scandinavia. We have a unique opportunity to build upon: (1) a statewide PBRN in Alabama developed in 2002, which already has one NIH-funded R01 clinical trial and one NIH-funded R21 study in progress; and (2) experience from large cross-sectional and longitudinal practice-based studies in Florida, Minnesota, the Pacific Northwest, and Scandinavia. Our application is best viewed as a joint response from the Network Chair and Coordinating Center applications - both groups must work well as a fully-integrated entity. The Dental PBRN's primary scientific aims are to: (1) accelerate development and conduct of clinical research; (2) perform relatively short-term studies to compare effectiveness of preventive and treatment methods; and (3) strengthen the knowledge base for clinical decision making. Secondary aims are to: (1) conduct anonymous chart reviews; (2) provide data on treatment trends; and (3) estimate prevalence of less-common conditions. The Dental PBRN organizational structure comprises the Network Chair administrative structure, the Coordinating Center, the Executive Committee, the Protocol Review Committee, Monitoring Boards, and NIDCR staff. This application details the Network Chair responsibilities with regard to overall scientific and administrative leadership; operations and fiscal management; duties on the Executive and Protocol Review Committees; recruiting, monitoring, certifying, and monitoring practitioner-investigators and their staff; systems to assist practitioner-investigators with patient recruitment and retention; stimulating and soliciting ideas for study protocols; fostering communication between all Dental PBRN components; leadership roles in manuscript preparation; and a plan to lead the agenda nationally toward translating science into the private practice setting. With NIDCR and local university funding, we have already completed substantial work to develop the Dental PBRN. For example, practitioner-investigators have already completed a 101-item practice characteristics questionnaire. We also have demonstrated """"""""proof of concept"""""""" for orienting and training dentists for PBRN research in general and Human Subjects training specifically. In addition to developing a Dental PBRN web site and clinical research software, we have garnered ideas for research projects from practitioner-investigators and held two meetings of our Interim Executive Committee. To our knowledge, we have more experience with dental practice-based research than any other team in the nation, which will enhance our anticipated success with the Dental PBRN. ? ?

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Project--Cooperative Agreements (U01)
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Study Section
Special Emphasis Panel (ZDE1-RR (02))
Program Officer
Denucci, D J
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University of Alabama Birmingham
Schools of Dentistry
United States
Zip Code
Makhija, Sonia K; Bader, James D; Shugars, Daniel A et al. (2018) Influence of 2 caries-detecting devices on clinical decision making and lesion depth for suspicious occlusal lesions: A randomized trial from The National Dental Practice-Based Research Network. J Am Dent Assoc 149:299-307.e1
Williams, Jessica H; DeLaughter, Kathryn; Volkman, Julie E et al. (2018) Exploring Online Asynchronous Counseling With Tobacco Treatment Specialists in the QUIT-PRIMO and National Dental PBRN HI-QUIT Studies: Who Uses It and What Do They Say? Am J Health Promot 32:1170-1177
Kakudate, Naoki; Yokoyama, Yoko; Sumida, Futoshi et al. (2017) Dentist Practice Patterns and Therapeutic Confidence in the Treatment of Pain Related to Temporomandibular Disorders in a Dental Practice-Based Research Network. J Oral Facial Pain Headache 31:152-158
Riley 3rd, J L; Gilbert, G H; Ford, G W et al. (2017) Judgment of the Quality of Restorative Care as Predictors of Restoration Retreatment: Findings from the National Dental PBRN. JDR Clin Trans Res 2:151-157
Mitchell, Sonya T; Funkhouser, Ellen; Gordan, Valeria V et al. (2017) Satisfaction with dental care among patients who receive invasive or non-invasive treatment for non-cavitated early dental caries: findings from one region of the National Dental PBRN. BMC Oral Health 17:70
Gordan, V V (2017) How to Bridge Research Results to Everyday Clinical Care? Oper Dent 42:1-9
Yokoyama, Yoko; Kakudate, Naoki; Sumida, Futoshi et al. (2016) Evidence-practice gap for in-office fluoride application in a dental practice-based research network. J Public Health Dent 76:91-7
Cutrona, Sarah L; Sadasivam, Rajani S; DeLaughter, Kathryn et al. (2016) Online tobacco websites and online communities-who uses them and do users quit smoking? The quit-primo and national dental practice-based research network Hi-Quit studies. Transl Behav Med 6:546-557
Nixdorf, Donald R; Law, Alan S; Lindquist, Kimberly et al. (2016) Frequency, impact, and predictors of persistent pain after root canal treatment: a national dental PBRN study. Pain 157:159-65
Yokoyama, Yoko; Kakudate, Naoki; Sumida, Futoshi et al. (2016) Evidence-practice gap for dental sealant application: results from a dental practice-based research network in Japan. Int Dent J 66:330-336

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