Abstract

We propose to utilize our large interstitial cystitis (IC) patient population to provide historical and clinical data, urine, serum and biopsy samples for a centralized depository of patient materials and a database. We currently see 135-145 new, symptomatic IC patients per year. These patients will provide the source of specimens. After eleven years of continued experience investigating and treating IC at UCSD, we have developed methods to obtain (via questionnaire) and analyze epidemiological and historical data. We have in the past 18 months accrued over 100 sets of patient materials which include the historical and clinical data, as well as, serum, urine, and biopsy specimens (fixed and cryo-preserved). These specimens have been shared with 5 other medical centers. The collaborative efforts with other centers has further helped in the development of techniques for storing data, retrieving and shipping pathological samples from IC patients for research purposes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK045026-02
Application #
3550924
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1991-09-30
Project End
1996-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Leiby, Benjamin E; Landis, J Richard; Propert, Kathleen J et al. (2007) Discovery of morphological subgroups that correlate with severity of symptoms in interstitial cystitis: a proposed biopsy classification system. J Urol 177:142-8
FitzGerald, M P; Brensinger, C; Brubaker, L et al. (2006) What is the pain of interstitial cystitis like? Int Urogynecol J Pelvic Floor Dysfunct 17:69-72
Tomaszewski, J E; Landis, J R; Russack, V et al. (2001) Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study. Urology 57:67-81
Akiyama, A; Stein, P C; Houshiar, A et al. (2000) Urothelial cytoprotective activity of Tamm-Horsfall protein isolated from the urine of healthy subjects and patients with interstitial cystitis. Int J Urol 7:176-83
Parsons, C L; Greenberger, M; Gabal, L et al. (1998) The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis. J Urol 159:1862-6;discussion 1866-7
Stein, P C; Pham, H; Ito, T et al. (1996) Bladder injury model induced in rats by exposure to protamine sulfate followed by bacterial endotoxin. J Urol 155:1133-8
Tay, H; Parsons, C L; Stein, P C (1996) Electrophysiologic monitoring of the effects of soluble virulence factors produced by Escherichia coli infection in urine. Urology 48:389-92
Tay, H P; Bidair, M; Shabaik, A et al. (1995) Primary yolk sac tumor of the prostate in a patient with Klinefelter's syndrome. J Urol 153:1066-9
Mostafavi, M; Stein, P C; Parsons, C L (1995) Production of soluble virulence factor by Escherichia coli. J Urol 153:1441-3
Niku, S D; Scherz, H C; Stein, P C et al. (1995) Intestinal de-epithelialization and augmentation cystoplasty: an animal model. Urology 46:36-9

Showing the most recent 10 out of 12 publications