This application emphasizes the ability of UT Southwestern group of investigators from the Departments of Urology and Urogynecology and their sub-contractor at North Texas Center for Urinary Control in Ft. Worth, TX to prospectively recruit a large cohort of women candidates, including ethnic minority women, for urinary incontinence surgery and follow them prospectively post-surgery. The five sites selected for participation in the Urinary Incontinence Treatment Network represent the most active, productive, and respected treatment centers for urinary incontinence in the current Dallas/Ft. Worth """"""""market."""""""" In addition to this unique grouping of talents and resources, the strengths of this application stem from: 1) broad clinical and surgical experience of the investigators with established reputations in female urology and urogynecology; 2) specialized and fully-dedicated patient care facilities with state-of-the-art urodynamic equipment and adjunctive modalities such as biofeedback; 3) well organized, efficient, and experienced clinical trial offices with documented on-going leadership in recruitment and retention of subjects through highly qualified, technical and administrative staff; 4) full institutional and multi-departmental support for the proposed program; 5) established collaborative relationship between the investigators in each sub-specialty; 6) recognized experience of the Principal investigator (PI) and most co-investigators in multi-centric cooperative projects; 7) close proximity and easy access to computerized database to ensure complete and timely transmission and management of all study data; and finally 8) a balanced budget encouraging the full participation of all five sites. This unique compilation of skill, experience, and facilities should contribute to a large enrollment of ethnically diverse women with urinary incontinence suitable for this trial.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DK060395-04S2
Application #
7251665
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kusek, John W
Project Start
2001-09-01
Project End
2006-09-29
Budget Start
2006-07-01
Budget End
2006-09-29
Support Year
4
Fiscal Year
2006
Total Cost
$89,335
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Urology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Thomas-White, Krystal J; Kliethermes, Stephanie; Rickey, Leslie et al. (2017) Evaluation of the urinary microbiota of women with uncomplicated stress urinary incontinence. Am J Obstet Gynecol 216:55.e1-55.e16
Norton, Peggy A; Nager, Charles W; Brubaker, Linda et al. (2016) The cost of preoperative urodynamics: A secondary analysis of the ValUE trial. Neurourol Urodyn 35:81-4
Zimmern, Philippe E; Gormley, E Ann; Stoddard, Anne M et al. (2016) Management of recurrent stress urinary incontinence after burch and sling procedures. Neurourol Urodyn 35:344-8
Mueller, Elizabeth R; Litman, Heather; Rickey, Leslie R et al. (2015) Comparison of flowrates and voided volumes during non-instrumented uroflowmetry and pressure-flow studies in women with stress incontinence. Neurourol Urodyn 34:549-53
Kenton, Kimberly; Stoddard, Anne M; Zyczynski, Halina et al. (2015) 5-year longitudinal followup after retropubic and transobturator mid urethral slings. J Urol 193:203-10
Guthrie, Katherine A; LaCroix, Andrea Z; Ensrud, Kristine E et al. (2015) Pooled Analysis of Six Pharmacologic and Nonpharmacologic Interventions for Vasomotor Symptoms. Obstet Gynecol 126:413-22
Sirls, Larry T; Tennstedt, Sharon; Brubaker, Linda et al. (2015) The minimum important difference for the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form in women with stress urinary incontinence. Neurourol Urodyn 34:183-7
Zyczynski, Halina M; Albo, Michael E; Goldman, Howard B et al. (2015) Change in Overactive Bladder Symptoms After Surgery for Stress Urinary Incontinence in Women. Obstet Gynecol 126:423-30
Brubaker, Linda; Litman, Heather J; Kim, Hae-Young et al. (2015) Missing data frequency and correlates in two randomized surgical trials for urinary incontinence in women. Int Urogynecol J 26:1155-9
Zimmern, Philippe; Litman, Heather J; Nager, Charles W et al. (2014) Effect of aging on storage and voiding function in women with stress predominant urinary incontinence. J Urol 192:464-8

Showing the most recent 10 out of 76 publications