Until recently, Type 2 diabetes (T2DM) was considered an adult disease. Increasing numbers of children and adolescents, primarily of African- American and Hispanic ethnicity, have been diagnosed with T2DM. The increased incidence of T2DM among children is a serious problem with significant implications for future morbidity and mortality from micro- and macro-vascular complications. Mean age of onset is 13.5 years. This is an especially severe problem in children from ethnic minority groups who are considered difficult to reach. Three risk factors have been associated with T2DM in children: family history of diabetes, obesity, and the presence of acanthosis nigricans. Of these, only obesity is preventable of reduce obesity. Prevention involves the adoption of healthy dietary and physical activity lifestyle behaviors that prevent or reduce obesity. Sixth grade is an important time for prevention because these children assume more responsibility for dietary and physical activity choices. School-based programs offer the best hope of reaching large numbers of these children and educating them to reduce their tasks. Family involvement is important, as the family provides the home environment and support for the dietary and physical activity behaviors. We propose to develop, implement, and evaluate a 5 component middle school-based intervention based on Social Cognitive Theory, targeting African-American and Hispanic children beginning at 11 years of age (6th grade) to reduce T2DM risks. Within the school environment, a cafeteria-based dietary intervention will promote water fruit, 100% fruit juice, vegetable and lower fat food consumption. 2. A physical education (PE) program will promote maintaining moderate to vigorous physical activity during a majority of the PE class period. 3. A club (to be named for focus groups) will be created during the school lung period under the sponsorship of the school nurse, and used to conduct behavior change activities encouraging water, fruit, 100% juice, vegetable, and lower fat food consumption and regular physical activity outside of school. These clubs will meet twice a month the first year, and monthly during the second and third years (7th and 8th grade), and use an intervention booklet that includes a photo novela like story line with goal setting and problem solving activities. 4. A series of 8 short video tapes on parenting in regard to children's healthy dietary and physical activity behaviors will be produced in English and Spanish, and mailed to the parents of the at risk students. 5. A motivational interview will be conducted with parents of the target child at baseline. Insulin sensitivity, weight, dietary and physical activity behaviors will be measured 4 times: baseline, after 1 year of intervention, and after the second and third years of intervention. We have substantial experience in designing, implementing, and evaluating behavioral change programs with children and their parents in both these ethnic groups. his theory-based program has the potential to enable youth to reduce their risks for T2DM. Tests of the proposed hypotheses will identify key variables mediating the intervention effects, and thereby elucidate our understanding of how behavior change programs work.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK061231-07
Application #
7426303
Study Section
Special Emphasis Panel (ZDK1-GRB-B (O1))
Program Officer
Linder, Barbara
Project Start
2002-03-15
Project End
2011-02-28
Budget Start
2008-03-01
Budget End
2011-02-28
Support Year
7
Fiscal Year
2008
Total Cost
$2,254,047
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Jago, R; Drews, K L; Otvos, J D et al. (2016) Novel measures of inflammation and insulin resistance are related to obesity and fitness in a diverse sample of 11-14 year olds: The HEALTHY Study. Int J Obes (Lond) 40:1157-63
Bauer, K W; Marcus, M D; El ghormli, L et al. (2015) Cardio-metabolic risk screening among adolescents: understanding the utility of body mass index, waist circumference and waist to height ratio. Pediatr Obes 10:329-37
Hernandez, Arthur E; Marcus, Marsha D; Hirst, Kathryn et al. (2014) Impact of implementation and conduct of the HEALTHY primary prevention trial on student performance. Am J Health Promot 29:55-8
Marcus, Marsha D; Foster, Gary D; El Ghormli, Laure (2014) Stability of relative weight category and cardiometabolic risk factors among moderately and severely obese middle school youth. Obesity (Silver Spring) 22:1118-25
Jago, Russell; Drews, Kimberly L; Otvos, James D et al. (2014) Effect of relative weight group change on nuclear magnetic resonance spectroscopy derived lipoprotein particle size and concentrations among adolescents. J Pediatr 164:1091-1098.e3
Kahn, Henry S; El ghormli, Laure; Jago, Russell et al. (2014) Cardiometabolic risk assessments by body mass index z-score or waist-to-height ratio in a multiethnic sample of sixth-graders. J Obes 2014:421658
Hall, William J; Schneider, Margaret; Thompson, Deborah et al. (2014) School factors as barriers to and facilitators of a preventive intervention for pediatric type 2 diabetes. Transl Behav Med 4:131-40
Jago, R; Mendoza, J A; Chen, T et al. (2013) Longitudinal associations between BMI, waist circumference, and cardiometabolic risk in US youth: monitoring implications. Obesity (Silver Spring) 21:E271-9
Schneider, Margaret; DeBar, Lynn; Calingo, Ashley et al. (2013) The effect of a communications campaign on middle school students' nutrition and physical activity: results of the HEALTHY study. J Health Commun 18:649-67
Marcus, Marsha D; Hirst, Kathryn; Kaufman, Francine et al. (2013) Lessons learned from the HEALTHY primary prevention trial of risk factors for type 2 diabetes in middle school youth. Curr Diab Rep 13:63-71

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