Abstract

UT Southwestern Prostate Disease Center investigators have worked together for more than a decade to study the pathogenesis of benign prostatic hyperplasia (BPH) from basic, translational and clinical research prospectives. Our investigators provided the major leadership for the design, supervision and conduct of the NIDDKK-funded MTOPS trial. Furthermore, the group has developed a substantial amount of preliminary data demonstrating the role of several biomarkers in the progression of BPH. Based upon this preliminary evidence, we propose to specifically validate the following biomarkers (or biomarker families) as markers of BPH progression: the prostatic smooth muscle contractile protein phenotype, prostatic alpha-2 macroglobulin, and type 2 5a-reductase. Further assay optimization will be performed with these three biomarkers using the UT Southwestern NIDDK-funded George W. O'Brien Tissue Repository, which contains more than 600 BPH samples and appropriate controls. After assay validation, we propose to test these three markers in the carefully phenotyped MTOPS tissue bank, where detailed correlation with prostate size, growth rate, symptomatic progression and response to therapy can be performed. Furthermore, we propose to explore the potential role of a unique signaling pathway (DOC-2) we believe is an important marker for stem cell proliferation in the prostate, as well as the potential role of telomerase expression in BPH progression in the development of prostatic cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK063661-02
Application #
6666837
Study Section
Special Emphasis Panel (ZDK1-GRB-3 (O1))
Program Officer
Mullins, Christopher V
Project Start
2002-09-30
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
2
Fiscal Year
2003
Total Cost
$394,566
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Urology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390