Abstract

Chronic prostatitis/chronic pelvic pain syndrome is a common but poorly understood condition affecting men of all ages. Infection has dominated the thinking about this disease for decades. However, a growing body of evidence provides significant challenge to the notion that infection contributes to symptoms in a significant proportion of patients. Much of this new information was developed by the Chronic Prostatitis Collaborative Research Network (CPCRN), a six year project representing the first NIH-funded collaborative study of chronic prostatitis. The long-term goal of this application is the continuation of our involvement in the Chronic Prostatitis Collaborative Research Network. In addition, we will collaborate with investigators studying interstitial cystitis under an umbrella group, the Urological Chronic Pelvic Pain Syndromes Collaborative Group. We describe the activities at our center over the past 7 years in the study of chronic prostatitis/chronic pelvic pain syndrome and describe the clinical and research infrastructure and experitise that we propose to continue to apply to the study of chronic prostatitis/chronic pelvic pain syndrome as part of this cooperative group.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DK065268-05S2
Application #
7415745
Study Section
Special Emphasis Panel (ZDK1-GRB-1 (M3))
Program Officer
Kusek, John W
Project Start
2003-09-05
Project End
2009-02-28
Budget Start
2007-03-01
Budget End
2009-02-28
Support Year
5
Fiscal Year
2007
Total Cost
$115,000
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Surgery
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Pontari, Michel A; Krieger, John N; Litwin, Mark S et al. (2010) Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial. Arch Intern Med 170:1586-93
Kouiavskaia, Diana V; Southwood, Scott; Berard, Carla A et al. (2009) T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome. J Urol 182:2483-9
Klyushnenkova, Elena N; Kouiavskaia, Diana V; Berard, Carla A et al. (2009) Cutting edge: permissive MHC class II allele changes the pattern of antitumor immune response resulting in failure of tumor rejection. J Immunol 182:1242-6
Nickel, J Curtis; Krieger, John N; McNaughton-Collins, Mary et al. (2008) Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome. N Engl J Med 359:2663-73
Kodak, James A; Mann, Dean L; Klyushnenkova, Elena N et al. (2006) Activation of innate immunity by prostate specific antigen (PSA). Prostate 66:1592-9