Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01DK078013-01
Application #
7248524
Study Section
Special Emphasis Panel (ZAI1-MP-I (M1))
Program Officer
Akolkar, Beena
Project Start
2006-09-20
Project End
2011-07-31
Budget Start
2006-09-20
Budget End
2007-07-31
Support Year
1
Fiscal Year
2006
Total Cost
$427,050
Indirect Cost
Name
La Jolla Institute
Department
Type
DUNS #
603880287
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Van Belle, Tom L; Pagni, Philippe P; Liao, Jeanette et al. (2014) Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes. J Autoimmun 55:24-32
Sarikonda, Ghanashyam; Fousteri, Georgia; Sachithanantham, Sowbarnika et al. (2014) BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells. PLoS One 9:e112242
Pagni, Philippe P; Bresson, Damien; Rodriguez-Calvo, Teresa et al. (2014) Combination therapy with an anti-IL-1? antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model. Diabetes 63:2015-25
Boettler, Tobias; Pagni, Philippe P; Jaffe, Rachel et al. (2013) The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes. J Autoimmun 44:40-8
Bresson, Damien; Fousteri, Georgia; Manenkova, Yulia et al. (2011) Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun 37:342-51
Van Belle, Tom L; Esplugues, Enric; Liao, Jeanette et al. (2011) Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol 187:2915-22
Boettler, Tobias; von Herrath, Matthias (2011) Protection against or triggering of Type 1 diabetes? Different roles for viral infections. Expert Rev Clin Immunol 7:45-53
van Belle, Tom L; Coppieters, Ken T; von Herrath, Matthias G (2011) Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 91:79-118
Bresson, Damien; von Herrath, Matthias (2011) Humanizing animal models: a key to autoimmune diabetes treatment. Sci Transl Med 3:68ps4
Martinic, Marianne M; Huber, Christoph; Coppieters, Ken et al. (2010) Expression level of a pancreatic neo-antigen in beta cells determines degree of diabetes pathogenesis. J Autoimmun 35:404-13

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