This is an application from the Washington University to continue to be a clinical site for the second phase of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The objectives of the LURN Study are to: (1) increase the understanding of lower urinary tract symptoms (LUTS) phenotypes and underlying mechanisms behind the patient subtypes and (2) develop a comprehensive, validated, and responsive measurement tools for defining treatment efficacy. After a successful initial 5-year funding cycle, LURN is prepared to build on the knowledge gained and take the next steps with the following Specific Aims:
Aim 1 : To refine and expand a clinically-relevant cluster model with a cohort of patients including wider range of symptom severity and a wider range of physiologic measures and followed for three years.
Aim 2 : To more deeply phenotype women with LUTS by measuring the functional components of the lower urinary tract (muscles of the bladder and urethra, and afferent and efferent nerves) in those with urinary urgency without incontinence, urinary urgency with incontinence, and normal controls.
Aim 3 : To identify a signature of proteins contained within plasma of specific subgroups of men and women with LUTS.
Aim 4 : To validate a comprehensive outcome tool for men and women with LUTS.
Aim 5 : To assess central sensitization in male and female patients with overactive bladder syndrome (OAB), compare their clinical phenotypes, cluster memberships, and serum protein signatures.

Public Health Relevance

In this project we strive to improve the care of patients who suffer from lower urinary tract symptoms (LUTS) by: (1) increasing the understanding of LUTS phenotypes and underlying mechanisms behind the patient subtypes, and (2) develop a comprehensive, validated, and responsive measurement tools for defining treatment efficacy for future LUTS clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01DK100017-06
Application #
9820406
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Mullins, Christopher V
Project Start
2013-07-15
Project End
2024-08-31
Budget Start
2019-09-09
Budget End
2020-08-31
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Helfand, Brian T; Smith, Abigail R; Lai, H Henry et al. (2018) Prevalence and Characteristics of Urinary Incontinence in a Treatment Seeking Male Prospective Cohort: Results from the LURN Study. J Urol 200:397-404
Andreev, Victor P; Liu, Gang; Yang, Claire C et al. (2018) Symptom Based Clustering of Women in the LURN Observational Cohort Study. J Urol 200:1323-1331
Cameron, Anne P; Lewicky-Gaupp, Christina; Smith, Abigail R et al. (2018) Baseline Lower Urinary Tract Symptoms in Patients Enrolled in LURN: A Prospective, Observational Cohort Study. J Urol 199:1023-1031
Griffith, James W; Messersmith, Emily E; Gillespie, Brenda W et al. (2018) Reasons for Seeking Clinical Care for Lower Urinary Tract Symptoms: A Mixed Methods Study. J Urol 199:528-535
Helmuth, Margaret E; Smith, Abigail R; Andreev, Victor P et al. (2018) Use of Euclidean length to measure urinary incontinence severity based on the lower urinary tract symptoms tool. Am J Obstet Gynecol 218:357-359
Lai, H Henry; Naliboff, Bruce; Liu, Alice B et al. (2018) The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations. Contemp Clin Trials 74:76-87
Siddiqui, Nazema Y; Wiseman, Jonathan B; Cella, David et al. (2018) Mental Health, Sleep and Physical Function in Treatment Seeking Women with Urinary Incontinence. J Urol 200:848-855
Cameron, Anne P; Smith, Abigail R; Lai, H Henry et al. (2018) Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence. Neurourol Urodyn 37:2586-2596
Bradley, Catherine S; Erickson, Bradley A; Messersmith, Emily E et al. (2017) Evidence of the Impact of Diet, Fluid Intake, Caffeine, Alcohol and Tobacco on Lower Urinary Tract Symptoms: A Systematic Review. J Urol 198:1010-1020
Yang, Claire C; Weinfurt, Kevin P; Merion, Robert M et al. (2016) Symptoms of Lower Urinary Tract Dysfunction Research Network. J Urol 196:146-52