The Prevention of Lower Urinary tract Symptoms (PLUS) Consortium is investing in understanding bladder health and lower-urinary track symptom prevention. The Consortium?s proposed healthy bladder definition is: ?A complete state of physical, mental, and social well-being related to bladder function and not merely the absence of lower urinary tract symptoms (LUTS). Healthy bladder function permits daily activities, adapts to short-term physical or environmental stressors, and allows optimal well-being.? We are only beginning to understand the risk and protective factors that can potentiate or destroy well-being across the spectrum?from having a healthy bladder to experiencing chronic LUTS. One overarching, powerful component is the act of drinking and the state of the bladder, or what we call the Beverages to Bladder (B2B) balance. Across the life course, B2B is a fact?what goes in must come out, usually through the bladder. Despite the obvious, little data exists to guide adolescent and adult women in the what, when, and why of choosing beverage type, volume, and timing of intake as it pertains to promoting their bladder health. Our broad goal is to know what beverage intake pattern(s) relate best to a truly healthy bladder. To reach this goal, we aim to: 1) Determine the distribution of bladder health across the spectrum from healthy bladder to chronic LUTS in U.S. adolescent and adult women, monitoring changes in bladder health over time across the life course; 2) Establish and validate the optimal B2B balance across the life course by identifying beverage intake patterns and determining which are associated with the range of the bladder health spectrum; and 3) Explore adolescent and adult women?s lived experiences of B2B balance, including the biological, interpersonal, sociocultural, and environmental influences?any of which might be early facilitators or barriers to optimizing B2B balance over the life course. We will work closely within the PLUS consortium to launch a large population based observational survey study to measure bladder health, including knowledge, attitudes, and beliefs; as well as risk and protective factors. We will also have available a new data collection tool for use in this longitudinal study called Where I Go, a phone application developed at The University of Michigan. It captures beverage intake in real time, toileting experiences, and other influences affecting how adolescent and adult women manage B2B in their day-to-day lives. This data will be analyzed along with survey information and data in other pre-existing datasets. Each component offers uniqueness that can help us identify women?s variations in beverage intake patterns, and how patterns relate to bladder health across the life course. We hypothesize there is a best pattern for optimizing bladder health, but there may be many reasons why a woman?s beverage intake differs from a best pattern. We will use adolescents and adult women focus groups combined with Where I Go to learn what influences beverage intake. Ultimately, we hope to gain new insights to inform interventions to help each woman understand her B2B balance and optimize it for bladder health.

Public Health Relevance

Currently, data are not available that can inform adolescent and adult women on recommendations for beverage intake pattern(s) that aid in achieving optimal bladder health. We aim to identify best beverage intake pattern(s) for preventing lower urinary tract symptoms across the life course by using an innovative mobile device application for collecting information in real time, along with a more traditional population-based survey study. Ultimately, we want to know how adolescent and adult women can optimize intake patterns to be most conducive to a truly healthy bladder, with lowest risk for developing lower urinary tract symptoms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01DK106893-06
Application #
10053405
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kirkali, Ziya
Project Start
2015-08-20
Project End
2025-06-30
Budget Start
2020-09-01
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Nursing
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109