The mechanistic underpinnings of diseases involving the exocrine pancreas are poorly understood. Chronic pancreatitis is often accompanied by inflammation of the pancreas, irreversible fibrosis, and destruction of the pancreatic parenchyma resulting in abdominal pain, malnutrition, exocrine pancreatic insufficiency, pancreatogenic diabetes, and, in some cases, pancreas cancer. We have developed a network of adult and pediatric investigators to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Clinical Centers (CPDPC-CCs) (U01), the OSU CC has helped develop four (4) major observational studies during the initial funding cycle to address research gaps in our understanding of diseases of the exocrine pancreas. Specifically, the OSU CC seeks to validate proposed diagnostic biomarkers in chronic pancreatitis, pancreatogenic diabetes, and pancreas cancer.

Public Health Relevance

We have developed a network of adult and pediatric medical research institutions to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC- CCs) (U01), the OSU CC has helped developed 4 major observational studies during the initial funding cycle that address research gaps in our understanding of the exocrine pancreas. Specifically, the OSU CC seeks to confirm and validate proposed diagnostic biomarkers in chronic pancreatitis, pancreaticogenic diabetes and pancreas cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01DK108327-06
Application #
10072698
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Unalp-Arida, Aynur
Project Start
2015-09-28
Project End
2025-06-30
Budget Start
2020-09-08
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
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Hart, Phil A; Andersen, Dana K; Mather, Kieren J et al. (2018) Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis Pancreas 47:1239-1243
Bennike, Tue Bjerg; Bellin, Melena D; Xuan, Yue et al. (2018) A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation. J Proteome Res 17:1983-1992

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